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Vasorin

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    Vasorin サマリー & タンパク質情報

    Vasorin 背景

    サブユニット構造: Interacts with TGFB1, TGFB2 and TGFB3. {ECO:0000269|PubMed:15247411}.
    細胞内位置: Membrane {ECO:0000305|PubMed:15247411}; Single-pass type I membrane protein {ECO:0000305|PubMed:15247411}. Secreted {ECO:0000269|PubMed:15247411}.
    組織特異性: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells. {ECO:0000269|PubMed:15247411}.
    翻訳後: N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor). {ECO:0000269|PubMed:15247411, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320}.
    シーケンスの類似性: Contains 1 EGF-like domain. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 1 fibronectin type-III domain. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 10 LRR (leucine-rich) repeats. {ECO:0000305}.; Contains 1 LRRCT domain. {ECO:0000305}.; Contains 1 LRRNT domain. {ECO:0000305}.
    General information above from UniProt

    Vasorin is a typical type I membrane protein. It contains 1 EGF-like domain, 1 fibronectin type-III domain, 10 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. Vasorin is predominantly expressed in vascular smooth muscle cells, and that its expression is developmentally regulated. vasorin It directly binds to transforming growth factor (TGF)-β and attenuates TGF-β signaling in vitro. This suggests that down-regulation of vasorin expression contributes to neointimal formation after vascular injury and that vasorin modulates cellular responses to pathological stimuli in the vessel wall.

    Vasorin 代替名

    SLITL2, [homo-sapiens]
    protein slit-like 2,SLITL2,slit-like 2,UNQ314/PRO357/PRO1282, [human]
    2610528G05Rik,Atia,protein slit-like 2,Slitl2,Slit-like 2, [mouse]
    Atia,Slitl2,2610528G05Rik, [mus-musculus]

    Vasorin 関連研究

  • Gerhard DS, et al. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14(10B):2121-7.
  • Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 44(2):325-40.
  • Lee KA, et al. (2011) Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. J Biol Chem. 286(48):41530-8.
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