TREM-2 Protein, Human, Recombinant (His Tag)

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TREM-2 Protein, Human, Recombinant (His Tag): 製品情報

純度
> 90 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the extracellular domain of human TREM2 (NP_061838.1) (Met 1-Ser 174) was expressed, fused with a polyhistidine tag at the C-terminus.
NP No.
発現ホスト
HEK293 Cells
Human
予測N末端
His 19
分子量
The secreted recombinant human TREM2 comprises 167 amino acids with a predicted molecular mass of 18.9 kDa. As a result of glycosylation, the apparent molecular mass of rhTREM2 is approximately 30-40 kDa band in SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile PBS, pH 7.4
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TREM-2 Protein, Human, Recombinant (His Tag): 画像

TREM-2 Protein, Human, Recombinant (His Tag): 別名

TREM-2 Protein, Human; Trem2a Protein, Human; Trem2b Protein, Human; Trem2c Protein, Human

TREM-2 背景情報

Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.
完全な名称
triggering receptor expressed on myeloid cells 2
参考文献
  • Bouchon, A. et al., 2000, J. Immunol. 164: 4991-4995.
  • Paloneva, J. et al., 2002, Am. J. Hum. Genet. 71:656-662. 
  • Prada, I. et al., 2006, Neuroscience. 140 (4): 1139-48.
  • Neumann, H. et al., 2007, J Neuroimmunol. 184 (1-2): 92-9.
  • Thrash, JC. et al., 2009, Neurochem Res. 34 (1): 38-45.
  • Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA
    Author
    Nakanishi, K;Morikane, S;Ichikawa, S;Kurohane, K;Niwa, Y;Akimoto, Y;Matsubara, S;Kawakami, H;Kobayashi, H;Imai, Y;
    Year
    2017
    Journal
    Sci Rep
    Application
    binding
  • The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
    Author
    Jendresen, C;Årskog, V;Daws, MR;Nilsson, LN;
    Year
    2017
    Journal
    J Neuroinflammation
    Application
    binding
  • Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup
    Author
    Woollacott, IOC;Nicholas, JM;Heslegrave, A;Heller, C;Foiani, MS;Dick, KM;Russell, LL;Paterson, RW;Keshavan, A;Fox, NC;Warren, JD;Schott, JM;Zetterberg, H;Rohrer, JD;
    Year
    2018
    Journal
    Alzheimers Res Ther
    Application
    ELISA (standard)
  • Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration
    Author
    Alosco, ML;Tripodis, Y;Fritts, NG;Heslegrave, A;Baugh, CM;Conneely, S;Mariani, M;Martin, BM;Frank, S;Mez, J;Stein, TD;Cantu, RC;McKee, AC;Shaw, LM;Trojanowski, JQ;Blennow, K;Zetterberg, H;Stern, RA;
    Year
    2018
    Journal
    Alzheimers Dement
    Application
    standard
  • The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk
    Author
    Deming, Y;Filipello, F;Cignarella, F;Hsu, S;Mikesell, R;Li, Z;Del-Aguila, J;Dube, U;Farias, F;Bradley, J;Cantoni, C;Benitez, B;Budde, J;Ibanez, L;Fernandez, M;et al.
    Year
    2018
    Journal
    bioRxiv
    Application
    ELISA (standard)
  • TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
    Author
    Zhao, Y;Wu, X;Li, X;Jiang, LL;Gui, X;Liu, Y;Sun, Y;Zhu, B;Piña-Crespo, JC;Zhang, M;Zhang, N;Chen, X;Bu, G;An, Z;Huang, TY;Xu, H;
    Year
    2018
    Journal
    Neuron
    Application
    Octet
  • CSF soluble TREM2 as a measure of immune response along the Alzheimer’s disease continuum
    Author
    Rauchmann, B;Schneider-Axmann, T;Alexopoulos, P;Perneczky, R;
    Year
    2018
    Journal
    Neurobiology of Aging
    Application
    ELISA
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