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トランスフォーミング成長因子-β (TGF-β) ファミリー

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Transforming Growth Factor Beta (TGF-beta) Family

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Transforming Growth Factor Beta (TGF-beta) Family

トランスフォーミング成長因子-β (TGF-β) ファミリー ELISA Kit Background

Transforming growth factor-beta 1 (TGF-beta 1), originally described in 1983, is the first member of the TGF-beta family. A number of closely related proteins designated TGF-beta 2-5 has been recognized. Since then, TGF-beta has been found to have a plethora of effects, such as regulation of cell growth, proliferation, differentiation, adhesion, migration, and apoptosis. Recent findings indicate that TGF-beta and other morphogens, such as BMP and Hedgehog, also serve as axon guidance molecules during development of the nervous system. TGF-beta's dual role as a tumor suppressor and promoter has also been discovered.