Band 3 / SLC4A1: Band 3 / SLC4A1 Protein | Band 3 / SLC4A1 Antibody

Band 3 / SLC4A1 Gene family

Band 3 / SLC4A1 Background

The Band 3 (AE1, SLC4A1) membrane protein is found in red blood cells and in kidney where it functions as an electro-neutral chloride/bicarbonate exchanger. Primary distal renal tubular acidosis (dRTA) caused by mutations of the SLC4A1 gene, which encodes for erythroid and kidney isoforms of anion exchanger, shows marked difference in inheritance patterns and clinical features in different parts of the world. Distal renal tubular acidosis caused by missense mutations in kidney isoform of anion exchanger 1 (kAE1/SLC4A1), the basolateral membrane Cl(-)/HCO3(-) exchanger of renal alpha-intercalated cells, has been extensively investigated in heterologous expression systems.

Reference for Band 3 / SLC4A1

  • Kalli AC, et al. (2018) Interaction of the human erythrocyte band 3 anion exchanger 1 (ae1, slc4a1) with lipids and glycophorin a: Molecular organization of the wright (wr) blood group antigen. PLoS Comput Biol 14(7), e1006284.
  • Park E, et al. (2018) Primary autosomal recessive distal renal tubular acidosis caused by a common homozygous slc4a1 mutation in two lao families. J Korean Med Sci 33(13), e95.
  • Vichot AA, et al. (2017) Loss of kae1 expression in collecting ducts of end-stage kidneys from a family with slc4a1 g609r-associated distal renal tubular acidosis. Clin Kidney J 10(1), 135-140.

Band 3 / SLC4A1 Protein

Band 3 / SLC4A1 protein function

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512}.

Band 3 / SLC4A1 protein expression

Tissue specificity

Detected in erythrocytes (at protein level) (PubMed:7506871, PubMed:26542571). Isoform 2 is expressed in kidney (at protein level) (PubMed:7506871).

Band 3 / SLC4A1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

Band 3 / SLC4A1 Antibody

There are 2 Band 3 / SLC4A1 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 2 Band 3 / SLC4A1 antibody for IHC-P. Among all these Band 3 / SLC4A1 antibodies, there are 2 anti-Band 3 / SLC4A1 rabbit polyclonal antibodies . All the Band 3 / SLC4A1 anbodies are produced in house and all are in stock. Band 3 / SLC4A1 antibody customerized service is available.

Band 3 / SLC4A1 Gene

SLC4A1 gene / cDNA is a protein-coding gene which located on 17q21.31. The SLC4A1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog.178 organisms have orthologs with human gene SLC4A1.