Anti-Renin Antibody

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Anti-Renin Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-Renin Antibody
検証済のアプリケーション
ELISA
交差反応
Reacts with: Mouse
特異性
Mouse Renin
免疫原
Recombinant Mouse REN1 protein (Catalog#50279-M08H)
調製
Produced in rabbits immunized with purified, recombinant Mouse REN1 (rM REN1; Catalog#50279-M08H; NP_112469.1; Met 1-Arg 402). Total IgG was purified by Protein A affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Renin Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Renin Antibody: 別名

Anti-D19352 Antibody; Anti-Ren Antibody; Anti-Ren-1 Antibody; Anti-Ren-2 Antibody; Anti-Ren-A Antibody; Anti-Ren-B Antibody; Anti-Ren1 Antibody; Anti-Ren1c Antibody; Anti-Ren1d Antibody; Anti-Ren2 Antibody; Anti-Rn-1 Antibody; Anti-Rn-2 Antibody; Anti-Rnr Antibody

Renin 背景情報

Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of thepeptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.
完全な名称
renin
参考文献
  • McKeon F.D., et al.,(1986), Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature 319:463-468.
  • Fisher D.Z., et al., (1986), cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.Proc. Natl. Acad. Sci. U.S.A. 83:6450-6454.
  • Sylvius N., et al.,(2005), In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients.J. Med. Genet. 42:639-647.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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