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Receptor Tyrosine Kinase, RTKs

Receptor Tyrosine Kinase (RTKs)Types

• EGFRs (epidermal growth factor receptor family ) • PDGFRs (platelet-derived growth factor receptor family )
• NGFRs (nerve growth factor receptors family ) • FGFRs (fibroblast growth factor receptor family )
• IGF1Rs (insulin-like growth factor-1 receptor family ) • INSR (insulin receptor family )
• MCSFRs (macrophage colony stimulating factor receptor family ) • VEGFRs (vascular endothelial growth factor receptor family )
• HGFRs (hepatocyte growth factor receptor family )  

Receptor Tyrosine Kinase (RTKs)Map

Receptor Tyrosine Kinase (RTKs)Reagents

Receptor Tyrosine Kinase (RTKs)Proteins

 
• High purity: > 95% • High Bio-activity • Low endotoxin: <1.0 EU/μg
Here are Receptor Tyrosine Kinase (RTKs)protein catalytic activity assay results
Mouse EphB1 protein (50479-M20B)
with Poly(Glu:Tyr) 4:1 substrate
Human EGFR / HER1 / ErbB1 protein
(10001-H20B2)with Poly(Glu:Tyr) 4:1 substrate
Human IGF1R / CD221 protein(10164-H20B1)
with Poly(Glu:Tyr) 4:1 substrate
 

Receptor Tyrosine Kinase (RTKs)Antibodies

 
• Various validated applications • Multiple species • High affinity & sensitivity
IHC IF FCM
Human EGFR/ErbB1/HER1 IHC antibody Human ErbB2/HER2 IF antibody Human Tie2 / CD202b / TEK FCM antibody
Human EGFR/ErbB1/HER1 in human placenta
(10001-R043)
Human ErbB2 in SKBR3 cells (10004-R002) Human Tie2 / CD202b / TEK in HUVEC cells
(10700-MM07-F)
 

Receptor Tyrosine Kinase (RTKs)Genes

 
• Expression validated • Multiple tags • Ready-to-use
GFP(GFPSpark®) Expression Validated OFP(OFPSpark®) Expression Validated
Human HER2/ERBB2 transcript variant 1 GeneORF cDNA clone expression plasmid Human HER2/ERBB2 transcript variant 1 GeneORF cDNA clone expression plasmid
Human HER2/ERBB2 transcript variant 1 GeneORF cDNA clone expression plasmid (HG10004-ACG) Human HER2/ERBB2 transcript variant 1 GeneORF cDNA clone expression plasmid (HG10004-ACR)
 

Receptor Tyrosine Kinase (RTKs)ELISAs

 
• High sensitivity
Human EGFR / HER1 / ErbB1 ELISA Kit Human FGFR2 / CD332 ELISA Kit Human EphB6 / Eph Receptor B6 ELISA Kit
Human EGFR / HER1 / ErbB1 ELISA Kit(KIT10001) Human FGFR2 / CD332 ELISA Kit(KIT10824) Human EphB6 / Eph Receptor B6 ELISA Kit
(KIT10197)

Receptors Tyrosine Kinases Background

Receptor tyrosine kinase (RTKs) is one of the major signaling enzymes in cell signal transduction,which act as receptors for growth factors, neurotrophic factors and other extracellular signaling molecules,upon ligand binding, they undergo tyrosine phosphorylation at specific residues in the cytoplasmic tail,This leads to the binding of protein substrates and/or the establishment of docking sites for adaptor proteins involved in RTK-mediated signal transduction.promotes cell growth, survival, and proliferation, It is also closely related to the proliferation, differentiation, migration and apoptosis of tumor cells.
Receptor tyrosine kinase (RTKs) is one of the most successful drug targets in 518 known hormones,It is also a very important tumor drug target and plays an important role in cancer therapy. There are more than 20 kinds of small molecule kinase inhibitors approved by FDA for various cancer treatments, and there are a large number of kinase inhibitors in various stages of clinical trials.

Receptors Tyrosine Kinases References

  • 1. Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases [J].Cell,2010 ,141(7):1117-34.
  • 2. Bennasroune A, et al. Tyrosine kinase receptors as attractive targets of cancer therapy[J]. Critical reviews in oncology/hematology, 2004, 50(1): 23-38.
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