RANKL cDNA Clone: Expression and Clone Vector / Plasmid
RANKL cDNA / Gene Overview
TNFSF11 gene / cDNA is a protein-coding gene which located on 13q14. The TNFSF11 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.220 organisms have orthologs with human gene TNFSF11.
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
RANKL cDNA / Gene Sequence
LOCUS NM_003701 2216 bp mRNA linear PRI 22-JUL-2018
Homo sapiens TNF superfamily member 11 (TNFSF11), transcript variant 1, mRNA.
This sequence information is just for reference only.