RANKL cDNA Clone: Expression and Clone Vector / Plasmid

RANKL cDNA / Gene Overview

TNFSF11 gene / cDNA is a protein-coding gene which located on 13q14. The TNFSF11 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.220 organisms have orthologs with human gene TNFSF11.

RANKL cDNA / Gene Function

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

RANKL cDNA / Gene Sequence

LOCUS
LOCUS NM_003701 2216 bp mRNA linear PRI 22-JUL-2018
DEFINITION
Homo sapiens TNF superfamily member 11 (TNFSF11), transcript variant 1, mRNA.
ACCESSION
NM_003701
VERSION
NM_003701.3

This sequence information is just for reference only.

RANKL Family & Reagents

RANKL Gene family reagents (CD molecules)

Approved Symbol Reagent list
CD274
LILRB2
CD3E
FCGR1A
SELPLG
THY1
CD96
TNFRSF10B
FGFR4
ITGB1
Approved Symbol Reagent list
CD81
DDR1
NCR3
TNFRSF1B
SPN
CD40LG
CD55
CD28
ICOS
IL3Ra

RANKL Gene family reagents (Tumor necrosis factor superfamily)

Approved Symbol Reagent list
CD40LG
FASLG
LTB
TNFSF10
TNFSF13
TNFSF14
TNFSF18
TNFSF8
Approved Symbol Reagent list
CD70
LTA
TNF
TNFSF12
TNFSF13B
TNFSF15
TNFSF4
TNFSF9

RANKL cDNA / Gene Alias

  • CD254
  • ODF
  • OPGL
  • RANKL
  • TRANCE

RANKL cDNA / Gene Expression

Biased expression in lymph node (RPKM 4.9), appendix (RPKM 2.0) and 6 other tissues