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Fc receptor

Function of Fc receptors:

  • 1. Involved in innate & adaptive immune system
  • 2. Activation of phagocytes
  • 3. Involved in antibody-dependent cell-mediated cytotoxicity (ADCC)
  • 4. Stimulate NK cells to release cytotoxic molecules
  • 5. Involved in allergic reactions
  • 6. Defense against parasitic infections.

Application of Fc receptors:

  • 1. ADCC activity evaluation of therapeutic monoclonal antibody
  • 2. Indicator of allergic reaction test
  • 3. PK/PD analysis of therapeutic monoclonal antibody
  • 4. Drug targets of potential autoimmune disease

Fc receptor Types & Molecules

Fc Receptor binding IgA Fc Receptor binding IgE Fc Receptor-Like molecule / FCRL
CD89/FCAR CD23/FCER2 MS4A2 FCRL1/FCRH1 FCRL4
  FcERI / FCER1A FCER1G FCRL3  
Fc Receptor binding IgG Fc Receptor binding IgA & IgM
CD64/FCGR1 CD16 / FCGR3 CD16b/FCGR3B FCAMR  
CD32a / FCGR2A CD16-2/FCGR4 FCGRT    
CD32b/FCGR2B CD16a/FCGR3A FCGRT & B2M    

Fc receptor reagent advantages

Fc receptor protein

 
• High purity: > 95% • Mutiple species • Low endotoxin: <1.0 EU/μg
• High Binding activity
FCGR2A/CD32a protein FCGRT & B2M protein FCGR2B / CD32b protein
FCGR2A / CD32a (10374-H08B)
binds to recombinant human IgG1
FCGRT & B2M (CT009-H08H)
binds to recombinant human IgG1
FCGR2B / CD32b (10259-H08H)
binds to recombinant human IgG1
 

Fc receptor Antibody

 
• Multiple applications • High affinity & sensitivity • Multiple antibody types
FCGR1/CD64 IHC antibody FCGR4 / CD16-2 IF antibody FCAR / CD89 FCM antibody
Detection of FCGR1 / CD64 in mouse liver by
immunohistochemistry (50086-R008)
Detectionof Mouse FCGR4 / CD16-2 in RAW264.7 cells
by immunofluorescence (50036-R012)
Flow cytometric analysis of anti-human
FCAR / CD89 antibody on human whole
blood monocytes (10414-MM02-P)
 

Fc receptor Gene

 
• Multiple species • Validated expression • Mutiple tags
Covering 5 species
including Human, Mouse, Rat, Rabbit, Cynomolgus
Enhanced promoter, full sequence validated,
ready-to-use
GFP, OFP, Myc, His, Flag, HA, untagged
 

Fc receptor ELISA Kit

 
• High specificity & stability • Low detection limit: 3.1 pg/ml
Cynomolgus CD16 ELISA Pair Set Human CD32b ELISA Pair Set Human CD89/FCAR ELISA Pair Set
Cynomolgus CD16 ELISA Pair Set Standard Curve (SEK90013) Human CD32b / FCGR2B ELISA Pair Set Standard Curve (SEKA10259) Human CD89/FCAR ELISA Pair Set Standard Curve (SEK10414)
注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"