Anti-PD-L2 Antibody

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Anti-PD-L2 Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-PD-L2 Antibody
検証済のアプリケーション
ELISA,IHC-P
交差反応
Reacts with: Human
特異性
Human PD-L2
免疫原
Recombinant Human PD-L2/B7-DC/CD273 Protein (Catalog#10292-H08H)
調製
Produced in rabbits immunized with purified, recombinant Human PD-L2/B7-DC/CD273 (rh PD-L2/B7-DC/CD273; Catalog#10292-H08H; NP_079515.2; Met1-Pro219). PD-L2/B7-DC/CD273 specific IgG was purified by Human PD-L2/B7-DC/CD273 affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A & Antigen Affinity
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-PD-L2 Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-PD-L2 Antibody (Rabbit Polyclonal 抗体) の画像

Immunochemical staining of human PD-L2 in human lymph node with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
Immunochemical staining of human PD-L2 in human appendix with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.

Anti-PD-L2 Antibody: 別名

Anti-B7-DC Antibody; Anti-B7DC Antibody; Anti-bA574F11.2 Antibody; Anti-Btdc Antibody; Anti-CD273 Antibody; Anti-PD-L2 Antibody; Anti-PDCD1L2 Antibody; Anti-PDL2 Antibody

PD-L2 背景情報

Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
完全な名称
programmed cell death 1 ligand 2
参考文献
  • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
  • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
  • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.

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