IkB alpha: IkB alpha Protein | IkB alpha Antibody

IkB alpha Gene family

IkB alpha Background

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Signal-induced degradation of I kappa B alpha exposes the nuclear localization signal of NF-kappa B, thus allowing it to translocate into the nucleus and activate transcription from responsive genes. An autoregulatory loop is established when NF-kappa B induces expression of the I kappa B alpha gene and newly synthesized I kappa B alpha accumulates in the nucleus where it negatively regulates NF-kappa B-dependent transcription. As part of this post-induction repression, the nuclear export signal on I kappa B alpha mediates transport of NF-kappa B-I kappa B alpha complexes from the nucleus to the cytoplasm. Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases.

Reference for IkB alpha

  • Verma IM, et al. (1995) Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9 (22): 2723-35.
  • Jacobs MD, et al. (1998) Structure of an IkappaBalpha/NF-kappaB complex. Cell 95 (6): 749-58.
  • Hay RT, et al. (1999) Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha. Philos Trans R Soc Lond B Biol Sci. 354(1389): 1601-9.
  • Spink CF, et al. (2007) Haplotypic structure across the I kappa B alpha gene (NFKBIA) and association with multiple myeloma. Cancer Lett. 246(1-2): 92-9.
  • Bredel M, et al. (2011) NFKBIA deletion in glioblastomas. N Engl J Med. 364(7): 627-37.

IkB alpha Protein

IkB alpha protein function

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:7479976}.

IkB alpha protein expression

Induction

Induced in adherent monocytes.

IkB alpha protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    317.00
  • Mass (Da)
    35.00

IkB alpha Antibody

There are 7 IkB alpha antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), FCM, ICC/IF, ELISA(Cap), WB, IP. There are 5 IkB alpha antibody for ELISA, 1 IkB alpha antibody for ELISA(Det), 2 IkB alpha antibody for FCM, 2 IkB alpha antibody for ICC/IF, 1 IkB alpha antibody for ELISA(Cap), 2 IkB alpha antibody for WB, 2 IkB alpha antibody for IP. Among all these IkB alpha antibodies, there are 3 anti-IkB alpha mouse monoclonal antibodies , 2 anti-IkB alpha rabbit monoclonal antibodies , 2 anti-IkB alpha rabbit polyclonal antibodies . All the IkB alpha anbodies are produced in house and all are in stock. IkB alpha antibody customerized service is available.

IkB alpha Gene

NFKBIA gene / cDNA is a protein-coding gene which located on 14q13.2. The NFKBIA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.230 organisms have orthologs with human gene NFKBIA.