ILT4: ILT4 Protein | ILT4 Antibody

ILT4 Gene family

ILT4 Background

ILT4, also known as LILRB2, is a member of the the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

Reference for ILT4

  • Colonna M., et al.,(1997), A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186:1809-1818.
  • Borges L., et al., (1997), A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.J. Immunol. 159:5192-5196.
  • Grimwood J., et al.,(2004), The DNA sequence and biology of human chromosome 19.Nature 428:529-535.

ILT4 Protein

ILT4 protein function

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.

ILT4 protein expression

Tissue specificity

Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.

ILT4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

ILT4 Antibody

There are 5 ILT4 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM. There are 2 ILT4 antibody for ELISA, 4 ILT4 antibody for FCM. Among all these ILT4 antibodies, there are 5 anti-ILT4 mouse monoclonal antibodies . All the ILT4 anbodies are produced in house and all are in stock. ILT4 antibody customerized service is available.

ILT4 Gene

LILRB2 gene / cDNA is a protein-coding gene which located on 19q13.4. 2 organisms have orthologs with human gene LILRB2.