Anti-LDLR / LDL Receptor Antibody (FITC)

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Anti-LDLR / LDL Receptor Antibody (FITC) (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-LDLR / LDL Receptor Antibody (FITC)
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human LDLR / LDL Receptor
免疫原
Recombinant Human LDL Receptor / LDLR protein (Catalog#10231-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human LDL Receptor / LDLR (rh LDL Receptor / LDLR; Catalog#10231-H08H; NP_000518.1; Met 1-Arg 788) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
ソース
Monoclonal Rabbit IgG Clone #301
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
標識物
FITC
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-LDLR / LDL Receptor Antibody (FITC) (Rabbit Monoclonal 抗体) の画像

Profile of anti-Human LDLR reactivity on HepG2 cells analyzed by flow cytometry.

Anti-LDLR / LDL Receptor Antibody (FITC): 別名

Anti-FH Antibody; Anti-FHC Antibody; Anti-LDL R Antibody; Anti-LDL Receptor Antibody; Anti-LDLCQ2 Antibody

LDLR / LDL Receptor 背景情報

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 84 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B1 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.
完全な名称
low density lipoprotein receptor
参考文献
  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.
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