Kininogen 1 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All Kininogen 1 reagents are produced in house and quality controlled, including 10 Kininogen 1 Antibody, 1 Kininogen 1 ELISA, 52 Kininogen 1 Gene, 2 Kininogen 1 Lysate, 2 Kininogen 1 Protein, 4 Kininogen 1 qPCR. All Kininogen 1 reagents are ready to use.

Kininogen 1 Protein (2)

    Kininogen 1 Antibody (10)

      Kininogen 1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      Kininogen 1 cDNA Clone (52)

      NM_001102416.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001102412.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_012696.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001009628.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Kininogen 1 Lysate (2)

        Kininogen 1 の背景知識

        Kininogen-1, also known as high molecular weight kininogen, williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1 and BDK, is a secreted protein which contains threecystatin domains. Kininogen-1 / KNG1 is a protein from the blood coagulation system as well as the kinin-kallikrein system. It is a protein that adsorbs to the surface of biomaterials that come in contact with blood. Kininogen-1 / KNG1 circulates throughout the blood and quickly adsorbs to the material surfaces. Kininogen-1 / KNG1 is one of the early participants of the intrinsic pathway of coagulation, together with Factor XII (Hageman factor) and prekallikrein. Kininogen-1 / KNG1 is one of thekininogens, a class of proteins. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed. When the clinical data were combined, it turned out that all patients, in fact, had a deficiency of the same protein. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) which is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.

        Kininogen 1 の参考文献

        • Ohkubo I., et al.,(1984), Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen. Biochemistry 23:5691-5697.
        • Takagaki Y., et al., (1985), Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.J. Biol. Chem. 260:8601-8609.
        • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.