kinase products center-enzyme

 Kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. Kinases are part of the larger family of phosphotransferases. Kinases are not to be confused with phosphorylases, which catalyze the addition of inorganic phosphate groups to an acceptor, nor with phosphatases, which remove phosphate groups. The phosphorylation state of a molecule, whether it be a protein, lipid, or carbohydrate, can affect its activity, reactivity, and its ability to bind other molecules. Therefore, kinases are critical in metabolism, cell signalling, protein regulation, cellular transport, secretory processes, and many other cellular pathways.

Protein kinases are a group of enzymes that add a phosphate group to proteins to change their activity. In this process, ATP or GTP is the phosphate group donor, while serine and threonine and tyrosine protein kinases are the receptor. The protein kinase structure is complicated. The function domain of the protein kinase is conservative, which usurally consists of 250 ~ 300 amino acids. Protein kinase can be classified by two ways, one is classified by substrates, including tyrosine kinase, serine threonine kinase and histidine kinase. The other is classified by catalytic domains, including AGC kinase, CAMK kinase, CK1 kinase, CMGC kinase, STE kinase, Tyrosine Kinase and TKL kinase.

Lipid kinases are one of the most promising new classes of potential drug targets. PI-3 and sphingosine kinases regulate a wide variety of cellular functions, including cell growth, proliferation, differentiation, motility, intracellular trafficking, and survival. As a result, defects in lipid kinase function lead to multiple disease states, including several forms of cancer and diabetes.

Protein kinase Lipid kinase

Protein kinase classified by catalytic domains

AGC Kinase molecule
AKT1 AKT2 AKT3 SGK1 SGK3 CDC42BPB
ROCK1 ROCK2 GRK1 GRK2 GRK3 GRK4
GRK5 GRK6 MASTL STK38 STK38L LATS1
LATS2 PDK1 PRKCA PRKCB PRKCD PRKCE
PRKCG PRKCI PRKCQ PRKCZ PKD2 PKD3
PKN2 PRKACA PRKACG RSK1 RSK2 RSK3
RSK4 MSK1 MSK2 P70S6K RPS6KB2 YANK2

CAM Kinase molecule
CAMK1 CAMK1D CAMK1G CAMK4 CAMK5 CAMK2A
CAMK2B CAMK2G AMPKA1 BRSK1 CHK1 CHK2
MELK MARK3 NIM1K PIM1 PIM2 PIM3
PRKD3 PRKD2 SIK1 SNRK STK11 STK33
STK40 TSSK2 TSSK6 TRIB1 TRIB2 TRIB3
DAPK1 DAPK2 DAPK3 DRAK1 MAPKAPK3 MAPKAPK5
MKNK1 MNK2 CASK Kinase DCAMKL1 OBSCN MYLK
MYLK2 MYLK3 PSKH1 SPEG CAMKK1  

Casein Kinase molecule
CSNK1A1 CSNK1A1L CSNK1G1 CSNK1G2 CSNK1G3 CSNK1D
CSNK1E VRK1 VRK3 CSNK2A1 CSNK2A2 CSNK2B

CMGC Kinase molecule
CDK1 CDK2 CDK3 CDK4 CDK5 CDK7
CDK8 CDK9 CDK10 CDK16 CDK17 CDK20
CDK2AP1 CDK2AP2 MAPK1 MAPK3 MAPK6 MAPK7
MAPK8 MAPK9 MAPK10 MAPK11 MAPK12 MAPK13
MAPK14 MAPK15 NLK CDKL2 CDKL3 CDKL4
CDKL5 CLK CLK2 CLK3 DYRK1B DYRK2
DYRK3 DYRK4 HIPK2 HIPK4 PRPF4B MOK
ICK SRPK SRPK2 SRPK3 GSK3B  

STE Kinase molecule
MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6
Map2k7 MAP3K2 MAP3K3 MAP3K7 MAP3K8 MAP3K14
PAK1 PAK2 PAK3 PAK4 PAK5 PAK6
PAK7 MST1 MST4 STK3 STK24 STK25
STK10 STRADB STRADA SLK OXSR1 TAOK3
TNIK MAP4K2 MAP4K5      

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Protein kinase classified by substrates

Tyrosine Kinase molecule
ABL1 ARG1 ARG2 TNK2 LTK AXL
TYRO3 MERTK PTK7 CSK MATK DDR1
DDR2 EGFR ERBB2 ERBB3 ERBB4 EPHA1
EphA2 EphA3 EphA4 EphA6 EphA7 EPHA8
EphB1 EphB2 EphB3 EphB4 EphB6 PTK2
FES FGFR1 FGFR2 FGFR3 FGFR4 FGFRL1
IGF1R INSR JAK1 JAK2 JAK3 TYK2
MET MST1R MUSK CSF1R PDGFRA PDGFRB
FLT3 KIT RET ROR1 ROR2 RYK
SRC YES1 FYN Lck LYN BLK
BRK1 SRM HCK YES1 FRK Syk
ZAP70 BTK BMX ITK TEC TEK
Tie1 NTRK1 NTRK2 NTRK3 FLT1 FLT4
KDR STYK1        

Tyrosine Kinase like group of kinase molecule
IRAK1BP1 IRAK2 Irak3 IRAK4 LIMK2 ILK
MAP3K7 MAP3K11 MAP3K13 ZAK ARAF BRAF
RAF1 RIPK1 RIPK2 RIPK3 RIPK4 ACVRL1
ACVR1 BMPR1A ACVR1B TGFBR1 BMPR1B ACVR1C
ACVR2B ACTR2 BMPR2 KSR2 TGFBR2  

Serine Threonine kinase molecule
AKT1 AKT2 AKT3 AMPK BRSK1 CAMK1
CAMK1D CAMK1G CAMK2A CAMK2B CAMK2G CAMK4
CAMKV CHEK1 CHEK2 CSNK2A1 CSNK2A2 CSNK2B
MAPK1 MAPK3 MAPK6 MAPK7 MAPK8 MAPK9
MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15
MELK NIM1K NLK NUAK2 PHKG1 PHKG2
PIM1 PIM2 PIM3 PKN2 PRKAA1 PRKACA
PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI
PRKCQ PRKCZ PRKD2 PRKD3 RAF1 SIK1
SNRK STK11 STK33 STK40 TRIB1 TRIB2
TRIB3 TSSK2 TSSK6 ADCK1 ADCK2 ADCK3
ADCK4 ADCK5 BCKDK BRD3 BRDT BuB1
BUB1B CDC7 CLK1 EEF2K EIF2AK1 MYT1
NEK2 NEK3 NEK6 NEK7 NEK8 NEK10
NEK11 NRBP1 PBK PDK2 PDK3 PDK4
PINK1 RIOK1 RIOK2 RIOK3 STK16 TBK1
TLK1 TLK2 TP53RK TTK ULK1 ULK3

Histidine kinase molecule
NME1 NME2

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Lipid Kinase molecule
HPGD PNPLA3 AMACR LPL /ARSA ASAH2
MVK PBEF PNPLA2 PNPLA3 CEL CES1
CES1D CES1F CES1G CES2 CES2A CES2E
CES3 CES3A GM4738 CES5 PLA2G1B PLA2G2A
PLA2G2D PLA2G2E PLA2G4A PLA2G4F PLA2G5 PLA2G7
PLA2G12B PLA2G15 ENPP2 ENPP3 ENPP4 ENPP5
ENPP7 PLD1 PON1 PON2 PON3 FASN
PCSK9 SGPL1 SMPD1 SMPD3 GK GK3
GK3P GK5 SPHK1 HAO1 LTA4H PIK3CA
PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R4
PIK3R6 DGKA DGKE DGKG DGKZ  

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Enzymes | Proteases | Kinases