Intracellular Kinases-enzyme

Protein kinases transfer phosphate groups from ATP to serine, threonine, or tyrosine residues on protein peptide substrates, directly affecting the activity and function of the target. Radiolabel studies suggest that approximately 30% of proteins in eukaryotic cells are subject to phosphorylation. Kinase activity, a crucial post-translational modification, regulates a broad range of cellular activities including the cell cycle, differentiation, metabolism, and neuronal communication. In addition, abnormal activity of Akt, ERK, JNK, PKC, PKA, p38, and other MAPK are implicated in many disease states. Sino Biological Inc. offers a range of quality products for the detection of protein phosphorylation, which include kinase activity assays, phospho-specific antibodies, ELISA, and more.

Extracellular signals, such as hormones, neurotransmitters, and growth factors, regulate a wide variety of cellular activities, including ion channel modulation, neuronal excitation, cell growth, cell differentiation, and insulin secretion events (1). Intracellular transduction systems receive these signals via receptors and transmit them quickly and precisely, resulting in the amplification of specific biological responses. However, cells often are exposed to several messengers simultaneously, and maintaining the fidelity of these networks is crucial in eliciting the appropriate physiological response. Doing so requires the accurate selection of effector molecules for regulated activation and deactivation, often by phosphorylation and dephosphorylation events. A principal strategy in achieving this selection specificity is compartmentalization of signaling enzymes

AKT Kinase
AKT1 AKT2/PKB beta AKT3
AMPK Kinase
PRKAA1 PRKAA2 PRKAB1
PRKAB2 PRKAG1 PRKAG2
PRKAG3    
CAM Kinase
CAMKI/CAMK1 CAMK1D/CKLiK CAMK1G
CAMK2A CAMK2B CaMKII/CAMK2G
CAMK4/CaMKIV CAMK5/CAMKV  
Casein Kinase
CSNK1A1 CSNK1A1L CSNK1G1
CSNK1G2 CSNK1G3 CSNK1D
CSNK1E VRK1 VRK3
CSNK2A1 CSNK2A2 CSNK2B
CDK Kinase
CDK1 CDK2 CDK3
CDK4 CDK5 CDK7
CDK8 CDK9 CDK10
CDK16 CDK17 CDK20
CDK2AP1 CDK2AP2  
DGK Kinase
DGKA DGKE DGKG
DGKZ    
DYRK Kinase
DYRK1B DYRK2 DYRK3
DYRK4    
ERK Kinase
ERK1/MAPK3 ERK2/MAPK1/MAPK2 ERK3/MAPK6
ERK5/BMK1/MAPK7    
GRK Kinase
GRK1 GRK2 / ADRBK1 GRK3/ADRBK2
GRK4 GRK5 GRK6
IKK Kinase
IKK alpha/NFKBIA IKK beta/IKBKB IKK epsilon/IKBKE/IKK-i
IRAK Kinase
IRAK2 IRAK3/IRAKM IRAK4
JAK Kinase
JAK1 JAK2 JAK3
TYK2    
JNK Kinase
JNK1/MAPK8 JNK2/MAPK9 JNK3/MAPK10
Carbohydrate Kinases
ADK FAM20B/Xylose kinase FAM20C/DMP4
FN3K Glucokinase/GCK GNE/GLCNE
HK1/Hexokinase 1 HK3/Hexokinase 3 NAGK
PFKFB3/PFK2 XYLB  
MAP3K Kinase
MAP3K2/MEKK2 MAP3K3/MEKK3 MAP3K7/TAK1
MAP3K8/MEKK8/TPL2 MAP3K14  
MAP2K Kinase
MEK1/MAP2K1/MKK1 MEK2/MAP2K2/MKK2 MEK2/MAP2K3/MKK3
MEK4/MAP2K4/MKK4 MEK5/MAP2K5/MKK5 MEK6/MAP2K6/MKK6
MEK7/MAP2k7/MKK7    
MSK Kinase
MSK1/RPS6KA5    
p38 MAP Kinases
MAPK11 MAPK12/SAPK3 MAPK13/p38 delta
MAPK14/p38 alpha    
PAK Kinase
PAK1 PAK2 PAK3
PAK4 PAK6 PAK7
PI3K Kinase
PIK3CA PIK3CB PIK3CD
PIK3CG/PI3K PIK3R1 PIK3R2
PIK3R4 PIK3R6  
PKC Kinase
PRKCA/PKCα PRKCB/PKCβ PRKCD/PKCδ
PRKCE/PKCε PRKCG/PKCγ PRKCI/PKCι
PRKCQ/PKCθ PRKCZ/PKCζ PKD2/PRKD2
PKD3/PRKD3 PKN2/PRK2  
PKA and PKG Kinase
PRKACA/PKACA PRKACG  
Polo-like Kinase
PLK1/PLK-1 PLK2 PLK3
PLK4/SAK    
SRC Kinase
RSK1/RPS6KA1 RSK2 RSK3/RPS6KA2
RSK4 MSK1 MSK2/RPS6KA4
P70S6K/RPS6KB1 RPS6KB2  
RSK Kinase
SRC YES1/c-Yes FYN
Lck LYN HCK
BLK/BLK Kinase FRK PTK6/Brk
Enzymes | Proteases | Kinases