ILT4 cDNA Clone: Expression and Clone Vector / Plasmid

ILT4 cDNA / Gene Overview

LILRB2 gene / cDNA is a protein-coding gene which located on 19q13.4. 2 organisms have orthologs with human gene LILRB2.

ILT4 cDNA / Gene Function

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ILT4 cDNA / Gene Sequence

LOCUS
LOCUS NM_001080978 2937 bp mRNA linear PRI 30-JUN-2018
DEFINITION
Homo sapiens leukocyte immunoglobulin like receptor B2 (LILRB2), transcript variant 2, mRNA.
ACCESSION
NM_001080978
VERSION
NM_001080978.3

This sequence information is just for reference only.

ILT4 Family & Reagents

ILT4 Gene family reagents (CD molecules)

Approved Symbol Reagent list
CLEC7A
CD8A
CEACAM5
TFRC
FZD4
CSF2RB
CD164
LAIR2
CD47
MS4A1
Approved Symbol Reagent list
TNFRSF13B
HAVCR1
LAMP3
CD200
CD36
KIT
NECTIN3
CD14
TNFRSF10C
DPP4

ILT4 Gene family reagents (Inhibitory leukocyte immunoglobulin like receptors)

Approved Symbol Reagent list
LILRB1
LILRB4
Approved Symbol Reagent list
LILRB3
LILRB5

ILT4 Gene family reagents (Ig-like cell adhesion molecule family)

Approved Symbol Reagent list
ICAM1
CNTN3
NECTIN4
CNTN4
CNTN6
CD244
CNTN2
NCAM1
NECTIN2
FGFRL1
Approved Symbol Reagent list
ROBO2
CNTN1
JAM3
JAM2
SIRPG
THY1
CHL1
L1CAM
MCAM
HEPACAM

ILT4 cDNA / Gene Alias

  • CD85d
  • ILT4
  • leucocyte Ig-like receptor B2
  • LIR2
  • LIR-2
  • MIR10
  • MIR-10
  • myeloid inhibitory receptor 10

ILT4 cDNA / Gene Expression

Biased expression in appendix (RPKM 54.6), bone marrow (RPKM 26.2) and 5 other tissues