IL-6 Protein

IL-6 Protein Overview

IL-6 reagents

IL6 is an immunoregulatory cytokine that activates a cell surface signaling assembly composed of IL6, IL6RA (IL6R; 147880), and the shared signaling receptor gp130 (IL6ST; 600694) (Boulanger et al., 2003).

IL-6 protein family

Belongs to the IL-6 superfamily.

IL-6 protein name

Recommended name
Interleukin-6
Short name
IL-6||BSF-2||CDF||IFN-beta-2
Aliases
BSF2, HGF, HSF, IL-6, interferon, beta 2
Alternative name
B-cell stimulatory factor 2 CTL differentiation factor Hybridoma growth factor Interferon beta-2

IL-6 Gene family protein

IL-6 Protein Sequence

Species Human IL-6 protein
Length 212
Mass (Da) 23718
Sequence Human IL-6 protein sequence
Species Mouse IL-6 protein
Length 211
Mass (Da) 24384
Sequence Mouse IL-6 protein sequence
Species Rat IL-6 protein
Length 211
Mass (Da) 24357
Sequence Rat IL-6 protein sequence

IL-6 Protein Molecular Weight & PI

Interleukin-6 precursor (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 30-212 Interleukin-6.

Molecular weight (Da)

20812.77

Theoretical pI

6.21

IL-6 Protein Structure

Crystal structure of the Fab portion of Olokizumab in complex with IL- 6
Deposited
2014-01-22   Released:  2014-04-30
Deposition Author(s)
Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A., Popplewell, A., Adams, R., Baker, T., Rapecki, S., Marshall, D., Neale, H., Lawson, A.
Organism(s)
Homo sapiens
Expression System
Cricetulus griseus, Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.2000 Å
R-Value Free
0.215
R-Value Work
0.176
4CNI From PDB

Human IL-6 protein Secondary structure

IL-6 Protein Interaction

Recombinant IL-6 Protein Feature

IL-6 Protein, Mouse, Recombinant

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.
High Activity
Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 0.4-2 ng/ml.

Recombinant IL-6 protein citations

Title
Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening
Year
2014
Author
LJ Liu, KH Leung, DSH Chan, YT Wang, DL Ma…
Journal
Cell Death and Disease
Title
Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38 MAPK signaling pathways.
Year
2016
Author
Yu, Q;Zeng, K;Ma, X;Song, F;Jiang, Y;Tu, P;Wang, X;
Journal
Int. Immunopharmacol.
Title
Early Interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor 魏B p65
Year
2017
Author
Shi, L;Zhao, D;Hou, C;Peng, Y;Liu, J;Zhang, S;Liu, J;Long, J;
Journal
Neurobiology of Aging
Title
Fettreiche Ernährung erhöht das Melanomzellwachstum in der Knochenmarks-Nische durch Induktion von Osteopontin und Interleukin 6
Year
2017
Author
Chen, G;
Journal
Thesis
Title
Prognostic significance of SOCS3 and its biological function in colorectal cancer
Year
2017
Author
Chu, Q;Shen, D;He, L;Wang, H;Liu, C;Zhang, W;
Journal
Gene
Title
Streptavidin-biotin-peroxidase nanocomplex-amplified microfluidics immunoassays for simultaneous detection of inflammatory biomarkers
Year
2017
Author
Wu, J;Chen, Y;Yang, M;Wang, Y;Zhang, C;Yang, M;Sun, J;Xie, M;Jian, X;
Journal
Analytica Chimica Acta
Title
The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-κB/IL-6/STAT3 signaling in hepatocellular carcinoma
Year
2018
Author
Lu, X;Wo, G;Li, B;Xu, C;Wu, J;Jiang, C;Wei, J;
Journal
Biomed. Pharmacother.
Title
The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-κB/IL-6/STAT3 signaling in hepatocellular carcinoma
Year
2018
Author
Lu, X;Wo, G;Li, B;Xu, C;Wu, J;Jiang, C;Wei, J;
Journal
Biomed. Pharmacother.
Title
Interleukin-6 Therapy Improves Intestinal Recovery Following Ischemia
Year
2019
Author
Te Winkel, JP;Drucker, NA;Morocho, BS;Shelley, WC;Markel, TA;
Journal
J. Surg. Res.

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