IL-6 cDNA Clone: Expression and Clone Vector / Plasmid

IL-6 cDNA / Gene Overview

IL6 gene / cDNA is a protein-coding gene which located on 7p15.3. The IL6 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, and chicken.198 organisms have orthologs with human gene IL6.

IL-6 cDNA / Gene Function

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

IL-6 cDNA / Gene Sequence

LOCUS
LOCUS NM_000600 1197 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens interleukin 6 (IL6), transcript variant 1, mRNA.
ACCESSION
NM_000600
VERSION
NM_000600.4

This sequence information is just for reference only.

IL-6 Family & Reagents

IL-6 Gene family reagents (Interferons)

Approved Symbol Reagent list
IFNA1
IFNA13
IFNA2
IFNA5
IFNA8
IFNG
IFNL2
IFNW1
Approved Symbol Reagent list
IFNA10
IFNA14
IFNA4
IFNA7
IFNB1
IFNL1
IFNL3
   

IL-6 Gene family reagents (Interleukins)

Approved Symbol Reagent list
IL18
IL7
IL4
IL36B
IL17C
IL17F
IL17B
IL16
IL9
IL25
Approved Symbol Reagent list
IL22
IL32
IL12A
IL1A
IL19
IL15
IL34
IL1B
IL13
IL1F10

IL-6 Gene family reagents (Interleukin 6 type cytokine family)

Approved Symbol Reagent list
CLCF1
CTF1
LIF
Approved Symbol Reagent list
CNTF
IL11
OSM

IL-6 cDNA / Gene Alias

  • BSF2
  • HGF
  • HSF
  • IL-6
  • interferon
  • beta 2

IL-6 cDNA / Gene Expression

Broad expression in urinary bladder (RPKM 9.7), gall bladder (RPKM 7.1) and 14 other tissues

Recombinant IL-6 protein citations

Title
An enzyme-mediated competitive colorimetric sensor based on Au@Ag bimetallic nanoparticles for highly sensitive detection of disease biomarkers
Year
2017
Author
Yin, B;Zheng, W;Dong, M;Yu, W;Chen, Y;Joo, SW;Jiang, X;
Journal
Analyst
Title
An enzyme-mediated competitive colorimetric sensor based on Au@Ag bimetallic nanoparticles for highly sensitive detection of disease biomarkers
Year
2017
Author
Yin, B;Zheng, W;Dong, M;Yu, W;Chen, Y;Joo, SW;Jiang, X;
Journal
Analyst
Title
Microglia activation induced by serum of SLE patients.
Year
2017
Author
Wang, J;Yang, C;Zhao, Q;Zhu, Z;Li, Y;Yang, P;
Journal
J. Neuroimmunol.