Anti-IL4R Antibody

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Anti-IL4R Antibody (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-IL4R Antibody
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human IL4R
免疫原
Recombinant Human IL-4R / CD124 Protein (Catalog#10402-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-4R / CD124 (rh IL-4R / CD124; Catalog#10402-H08H; NP_000409.1; Met1-His232).
ソース
Monoclonal Rabbit IgG Clone #209
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IL4R Antibody (Rabbit Monoclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IL4R Antibody (Rabbit Monoclonal 抗体) の画像

Flow cytometric analysis of Human IL4R(CD124) expression on human whole blood lymphocytes. Cells were stained with purified anti-Human IL4R(CD124), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

Anti-IL4R Antibody: 別名

Anti-CD124 Antibody; Anti-IL-4RA Antibody; Anti-IL4R Antibody; Anti-IL4RA Antibody

IL4R 背景情報

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.
完全な名称
interleukin 4 receptor
参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.

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