GPR56 is a member of an adhesion G protein-coupled receptor family with a very long N-terminal stalk and seven transmembrane domains. GPR56 may be a target for the treatment of type 2 diabetes. GPR56 inhibits melanoma metastatic growth by impeding the expansion of micrometastases to macrometastases. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo.
adhesion G protein-coupled receptor G1
Liu M., et al., 1999, Genomics 55: 296-305.
Huang,Y. et al., 2008, Mol Cell Biochem. 308 (1-2):133-9.