Her2 / ERBB2 cDNA ORF Clone, Human, untagged

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Her2 / ERBB2 cDNA ORF Clone, Human, untagged: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
3768 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence.
製品の特徴
Full length Clone DNA of Human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), transcript variant 1.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
制限部位
HindIII + XbaI(6.1kb+3.77kb)
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

Her2 / ERBB2 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Her2 / ERBB2 cDNA ORF Clone, Human, untagged: 検証済の画像

Her2 / ERBB2 cDNA ORF Clone, Human, untagged: 別名

CD340 cDNA ORF Clone, Human; ENV cDNA ORF Clone, Human; ENVW cDNA ORF Clone, Human; ERVWE1 cDNA ORF Clone, Human; HER-2 cDNA ORF Clone, Human; HER-2/neu cDNA ORF Clone, Human; HER2 cDNA ORF Clone, Human; HERV-7q cDNA ORF Clone, Human; HERV-W-ENV cDNA ORF Clone, Human; HERV7Q cDNA ORF Clone, Human; HERVW cDNA ORF Clone, Human; HERVWENV cDNA ORF Clone, Human; MLN 19 cDNA ORF Clone, Human; MLN19 cDNA ORF Clone, Human; NEU cDNA ORF Clone, Human; NGL cDNA ORF Clone, Human; TKR1 cDNA ORF Clone, Human

Her2 / ERBB2 背景情報

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
完全な名称
erb-b2 receptor tyrosine kinase 2
参考文献
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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