Focal adhesion Kinase-FAK-enzyme

Focal adhesion kinase family is a newly defined kinase family which consists of two family members, FAK (PTK2) and PYK2. The first FAK family member is FAK (PTK2) which was found as an integrin-dependent phosphorylated protein. Integrin-mediated cell adhesion causes phosphorylation of FAK, a 120 kDa protein. FAK is the first identified signaling molecule among integrins.

Structure of Focal adhesion kinase (FAK) family members.

Function of FAKs

A functional FAK is required for embryonic development. Results have shown that disruption of FAK in mice is embryonic lethal and a pronounced defect in cell migration. Current studies have shown that FAK expression is associated with cancer. Increased FAK mRNA expression was observed in most cancer tissue samples but not in normal samples. Another study also showed that the increased level is relative high with a 100% increase in colon tumor samples. The mechanism of increased FAK expression is still under investigation. Furthermore, FAK also has a role in angiogenesis as FAK is expressed in the developing vasculature during embryogenesis.

FAK list
Enzymes | Proteases | Kinases
Proteases products center
kinase products center
Protein Kinase Introduction
Protein kinase classified by catalytic domains
Protein kinase classified by substrates+
- Tyrosine Kinase
- tyrosine-kinase like group of kinases
- Receptor Tyrosine Kinase (RTKs)
- Non-Receptor Tyrosine Kinase (PTKS)
Janus Kinase-JAK
Focal adhesion Kinase-FAK
TEC Kinase
SRC Kinase
ABL Kinase
Spleen tyrosiine Kinase-SYK
Fyn-related kinase-FRK
FES Kinase
C-terminal Src kinase-CSK
ACK Kinase
- Serine Threonine Kinase
- Histidine Kinase-HK
Protein Kinase Inhibitor
Dual specificity kinase
Intracellular Kinases
Protein kinase related to signaling pathway
Protein Kinase in the Akt Pathway
Protein Kinase in Apoptosis Regulation
Lipid Kinase
Other Enzymes products center