FGF10 Protein, Human, Recombinant

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FGF10 Protein, Human, Recombinant: 製品情報

純度
> 98 % as determined by SDS-PAGE
内毒素
Please contact us for more information.
活性
Measured by its binding ability in a functional ELISA.
Immobilized humen FGF10 at 10 μg/ml (100 μl/well) can bind Cynomolgus FGFR1-Fc (Cat:90075-C02H) with a linear range of 31.25-2000 ng/mL.
タンパク質の構築
A DNA sequence encoding the mature form of human FGF10 (NP_004456.1) (Gln 38-Ser 208) was expressed.
NP No.
発現ホスト
E. coli
Human
予測N末端
Met
分子量
The recombinant human FGF10 consists of 172 amino acids and has a predicted molecular mass of 19.6 kDa as estimated in SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile 20mM Tris, pH 7.5
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FGF10 Protein, Human, Recombinant: 画像

FGF10 Protein, Human, Recombinant: 別名

KGF2 Protein, Human

FGF10 背景情報

Fibroblast growth factor 1 (FGF1) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF1 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF1 plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. FGF1 is required for normal branching morphogenesis. It may play a role in wound healing. Defects in FGF1 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG). ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
完全な名称
fibroblast growth factor 10
参考文献
  • Sekine K, et al. (1999) Fgf10 is essential for limb and lung formation. Nat Genet. 21(1): 138-41.
  • Ohuchi H, et al. (2000) FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem Biophys Res Commun. 277(3): 643-9.
  • Bellusci S, et al. (1997) Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development. 124(23): 4867-78.
  • Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification
    Author
    Jiang, K;Tang, Z;Li, J;Wang, F;Tang, N;
    Year
    2018
    Journal
    Sci Rep
    Application
    tissue-based
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