EPOR cDNA Clone: Expression and Clone Vector / Plasmid
EPOR cDNA / Gene Overview
EPOR gene / cDNA is a protein-coding gene which located on 19p13.2. The EPOR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.144 organisms have orthologs with human gene EPOR.
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
EPOR cDNA / Gene Sequence
LOCUS NM_000121 2459 bp mRNA linear PRI 12-AUG-2018
Homo sapiens erythropoietin receptor (EPOR), transcript variant 1, mRNA.
This sequence information is just for reference only.