EPOR cDNA Clone: Expression and Clone Vector / Plasmid

EPOR cDNA / Gene Overview

EPOR gene / cDNA is a protein-coding gene which located on 19p13.2. The EPOR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.144 organisms have orthologs with human gene EPOR.

EPOR cDNA / Gene Function

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

EPOR cDNA / Gene Sequence

LOCUS
LOCUS NM_000121 2459 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens erythropoietin receptor (EPOR), transcript variant 1, mRNA.
ACCESSION
NM_000121
VERSION
NM_000121.3

This sequence information is just for reference only.

EPOR Family & Reagents

EPOR Gene family reagents (Fibronectin type III domain containing)

Approved Symbol Reagent list
LIFR
FLRT2
CHL1
FNDC4
MERTK
EphA6
FLRT3
EphA7
EPHA1
IL7R
Approved Symbol Reagent list
CSF2RB
CSF3R
MPL
FN1
CNTN2
AXL
EphA3
OSMR
INSR
IL27Ra

EPOR cDNA / Gene Expression

Broad expression in bone marrow (RPKM 14.6), thyroid (RPKM 11.4) and 22 other tissues