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EBOV-G/Ebola Glycoprotein  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Baculovirus-Insect Cells  
40094-V08B2-20
40094-V08B2-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
40304-VCCH1-20
40304-VCCH1-100
20 µg 
100 µg 
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  • Slide 1
発現宿主: Human Cells  
40368-V02H1-20
40368-V02H1-100
20 µg 
100 µg 
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  • Slide 1
発現宿主: Human Cells  
40094-V02H1-20
40094-V02H1-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
40094-V08H1-20
40094-V08H1-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Baculovirus-Insect Cells  
40368-V08B-20
40368-V08B-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
製品の説明:   
発現宿主: Human Cells  
40094-V08H-20
40094-V08H-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
製品の説明:   
発現宿主: Baculovirus-Insect cells  
40094-V08B1-20
40094-V08B1-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Baculovirus-Insect Cells  
40304-V08B1-20
40304-V08B1-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
製品の説明:   
発現宿主: Baculovirus-Insect Cells  
40442-V08B1-20
40442-V08B1-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
40094-V08H2-20
40094-V08H2-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
40304-V08H-20
40304-V08H-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
製品の説明:   
発現宿主: Baculovirus-Insect Cells  
40094-V08B-20
40094-V08B-100
20 µg 
100 µg 
Add to Cart
  • Slide 1

EBOV-G/Ebola Glycoprotein Related Area

EBOV-G/Ebola Glycoprotein 関連経路

    EBOV-G/Ebola Glycoprotein サマリー & タンパク質情報

    EBOV-G/Ebola Glycoprotein 背景

    The fourth gene of the EBOV genome encodes a 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD); the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, β-integrins, folate receptor-α, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry; the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm.

    EBOV-G/Ebola Glycoprotein 代替名

    Ebola Glycoprotein, []

    EBOV-G/Ebola Glycoprotein 関連研究

    1. Volchkov VE, et al. Processing of the Ebola virus glycoprotein by the proprotein convertase furin. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5762-7.
    2. Lee JE, et al. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 2008 Jul 10;454(7201):177-82. doi: 10.1038/nature07082.
    3. Hood CL, et al. Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity. J Virol. 2010 Mar;84(6):2972-82. doi: 10.1128/JVI.02151-09.
    4. Cook JD and Lee JE. The secret life of viral entry glycoproteins: moonlighting in immune evasion. PLoS Pathog. 2013 May;9(5):e1003258. doi: 10.1371/journal.ppat.1003258.
    5. Miller EH and Chandran K. Filovirus entry into cells - new insights. Curr Opin Virol. 2012 Apr;2(2):206-14. doi: 10.1016/j.coviro.2012.02.015.
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