DNMT3A cDNA Clone: Expression and Clone Vector / Plasmid
DNMT3A cDNA / Gene Overview
DNMT3A gene / cDNA is a protein-coding gene which located on 2p23.3. The DNMT3A gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.185 organisms have orthologs with human gene DNMT3A.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
DNMT3A cDNA / Gene Sequence
LOCUS NM_022552 4324 bp mRNA linear PRI 22-JUL-2018
Homo sapiens DNA methyltransferase 3 alpha (DNMT3A), transcript variant 3, mRNA.
This sequence information is just for reference only.
DNMT3A cDNA / Gene Expression
Ubiquitous expression in placenta (RPKM 5.8), ovary (RPKM 3.9) and 25 other tissues