DNMT3A cDNA Clone: Expression and Clone Vector / Plasmid

DNMT3A cDNA / Gene Overview

DNMT3A gene / cDNA is a protein-coding gene which located on 2p23.3. The DNMT3A gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.185 organisms have orthologs with human gene DNMT3A.

DNMT3A cDNA / Gene Function

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]

DNMT3A cDNA / Gene Sequence

LOCUS
LOCUS NM_022552 4324 bp mRNA linear PRI 22-JUL-2018
DEFINITION
Homo sapiens DNA methyltransferase 3 alpha (DNMT3A), transcript variant 3, mRNA.
ACCESSION
NM_022552
VERSION
NM_022552.4

This sequence information is just for reference only.

DNMT3A cDNA / Gene Expression

Ubiquitous expression in placenta (RPKM 5.8), ovary (RPKM 3.9) and 25 other tissues