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IL3RA / CD123 抗体, ウサギモノクローナル抗体

データシートレビュープロトコル
製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10518-H08H-50
10518-H08H-20
50 µg 
20 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10518-H03H-50
10518-H03H-20
50 µg 
20 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
50810-M08H-50
50810-M08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
50810-M02H-20
50810-M02H-100
20 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
70077-D08H-20
70077-D08H-10
20 µg 
10 µg 
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IL3RA/CD123 ELISA Pair Set

検出限界: 31.25 pg/ml
SEK10518-5
SEK10518-15
5 Plates 
15 Plates 
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IL3RA/CD123 antibody 背景

Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and / or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.

人々 IL3RA/CD123 antibody 参考文献
  • Del Giudice I, et al. (2004) The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica. 89(3): 303-8.
  • Du X, et al. (2007) New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. J Immunother. 30(6): 607-13.
  • Yue LZ, et al. (2010) Expression of CD123 and CD114 on the bone marrow cells of patients with myelodysplastic syndrome. Chin Med J (Engl). 123(15): 2034-2037.
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