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IL-21R / Il21R 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

データシートレビュープロトコル
製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
11483-H08H-200
11483-H08H-100
200 µg 
100 µg 
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発現宿主: Human Cells  
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51184-M02H-20
51184-M02H-100
20 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
51184-M08H-20
51184-M08H-100
20 µg 
100 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
80189-R05H-50
80189-R05H-200
50 µg 
200 µg 
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発現宿主: Human Cells  
  • Slide 1
80189-R08H-50
80189-R08H-100
50 µg 
100 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
90315-C02H-200
90315-C02H-100
200 µg 
100 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
90315-C08H-200
90315-C08H-100
200 µg 
100 µg 
Add to Cart

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IL-21R antibody 背景

Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.

ラット IL-21R antibody 参考文献
  • Asao H, et al. (2001) Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 167(1): 1-5.
  • Wu Z, et al. (2005) Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol. 25(22): 9741-52.
  • De Totero D, et al. (2006) Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood. 107(9): 3708-15.
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