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FGFR3 / CD333 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

データシートレビュープロトコル
発現宿主: Human Cells  
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16486-H02H-50
16486-H02H-200
50 µg 
200 µg 
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発現宿主: Human Cells  
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16486-H08H-50
16486-H08H-200
50 µg 
200 µg 
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発現宿主: Human Cells  
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16044-H08H-50
16044-H08H-200
50 µg 
200 µg 
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発現宿主: Human Cells  
  • Slide 1
16044-H02H-50
16044-H02H-200
50 µg 
200 µg 
Add to Cart
製品の説明: Active  
発現宿主: Human Cells  
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50071-M03H-50
50071-M03H-100
50 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
50071-M08H-50
50071-M08H-100
50 µg 
100 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
90313-C02H-50
90313-C02H-100
50 µg 
100 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
90313-C08H-50
90313-C08H-100
50 µg 
100 µg 
Add to Cart

FGFR3/CD333 ELISA Pair Set

検出限界:
SEK50071-5
SEK50071-15
5 Plates 
15 Plates 
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FGFR3/CD333 AntibodyRelated Products

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FGFR3/CD333 antibody 背景

FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

マウス FGFR3/CD333 antibody 参考文献
  • Keegan K, et al. (1991) Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc Natl Acad Sci. 88(4):1095-9.
  • Hafner C, et al. (2007) FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin. J Invest Dermatol. 127(7):1572-3.
  • Lamy A, et al. (2006) Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations. J Urol. 176(6 Pt 1):2686-9.
  • Schweitzer DN, et al. (2001) Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu substitution in FGFR3. Am J Med Genet. 98 (1):75-91.
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