Text Size:AAA

人々 IGF-1 / IGF-I / IGF1 蛋白質

データシートレビュープロトコル
反応度: Human  
アプリケーション: ELISA  
    10598-R023-50
    10598-R023-100
    50 µg 
    100 µg 
    Add to Cart

    IGF1/IGF‑I/IGF-1 Recombinant ProteinRelated Products

    Related Products

    Featured Reagent Products

    IGF1/IGF‑I/IGF-1 protein 背景

    IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

    人々 IGF1/IGF‑I/IGF-1 protein 参考文献
    注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"