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ラット Siglec-2 / CD22 蛋白質 (ECD, Fc タグ)

データシートレビュープロトコル
反応度: Human  
アプリケーション: 
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11958-T26-50
11958-T26-200
11958-T26-100
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200 µg 
100 µg 
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反応度: Human  
アプリケーション: ELISA  IF  ICC/IF  
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11958-R340-50
11958-R340-100
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100 µg 
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反応度: Human  
アプリケーション: ELISA  
    11958-RP01-400
    11958-RP01-200
    11958-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反応度: Human  
    アプリケーション: 
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    11958-MM13-C-25
    11958-MM13-C-100
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    反応度: Human  
    アプリケーション: FCM  
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    11958-MM13-F-25
    11958-MM13-F-100
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    100 Tests 
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    反応度: Human  
    アプリケーション: ELISA  IHC-P  
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    11958-MM12-50
    11958-MM12-200
    11958-MM12-100
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    反応度: Human  
    アプリケーション: ELISA  
      11958-MM07-50
      11958-MM07-200
      11958-MM07-100
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      反応度: Human  
      アプリケーション: 
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      11958-MM13-P-25
      11958-MM13-P-100
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      反応度: Human  
      アプリケーション: FCM  
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      11958-MM13-50
      11958-MM13-200
      11958-MM13-100
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      200 µg 
      100 µg 
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      反応度: Mouse  
      アプリケーション: FCM  
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      51177-R060-P-25
      51177-R060-P-100
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      100 Tests 
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      反応度: Mouse  
      アプリケーション: 
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      51177-R060-A-25
      51177-R060-A-100
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      反応度: Mouse  
      アプリケーション: FCM  
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      51177-R026-P-25
      51177-R026-P-100
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      反応度: Mouse  
      アプリケーション: WB  IP  
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      51177-R087-50
      51177-R087-100
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      100 µg 
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      反応度: Mouse  
      アプリケーション: WB  
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      51177-R078-50
      51177-R078-100
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      100 µg 
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      反応度: Mouse  
      アプリケーション: FCM  
      • Slide 1
      51177-R026-50
      51177-R026-100
      50 µg 
      100 µg 
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      反応度: Mouse  
      アプリケーション: FCM  
      • Slide 1
      51177-R060-F-25
      51177-R060-F-100
      25 Test 
      100 Tests 
      Add to Cart
      反応度: Mouse  
      アプリケーション: ELISA  
        51177-R064-50
        51177-R064-100
        50 µg 
        100 µg 
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        反応度: Mouse  
        アプリケーション: FCM  
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        51177-R060-50
        51177-R060-100
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        100 µg 
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        反応度: Rat  
        アプリケーション: ELISA  
          81343-RP01-400
          81343-RP01-200
          81343-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          反応度: Rat  
          アプリケーション: ELISA  IHC-P  
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          81343-T24-50
          81343-T24-200
          81343-T24-100
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          200 µg 
          100 µg 
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          反応度: Rat  
          アプリケーション: 
            81343-R072-50
            81343-R072-100
            50 µg 
            100 µg 
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            CD22/Siglec-2 protein 背景

            CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.

            Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            ラット CD22/Siglec-2 protein 参考文献
          • Tedder TF, et al. (1997) CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Annu Rev Immunol. 15: 481-504.
          • Tedder TF, et al. (2005) CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol. 88: 1-50.
          • Fujimoto M, et al. (2007) B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity. J Dermatol Sci. 46(1): 1-9.
          • Walker JA, et al. (2008) CD22: an inhibitory enigma. Immunology. 123(3): 314-25.
          • Nitschke L. (2009) CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions. Immunol Rev. 230(1): 128-43.
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