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人々 IGF-2 / IGF-II 蛋白質

データシートレビュープロトコル
反応度: Human  
アプリケーション: ELISA  
    13032-RP01-400
    13032-RP01-200
    13032-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反応度: Human  
    アプリケーション: ELISA  
      13032-T16-50
      13032-T16-200
      13032-T16-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反応度: Mouse  
      アプリケーション: ELISA  
        50040-T16-50
        50040-T16-200
        50040-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反応度: Mouse  
        アプリケーション: ELISA  
          50040-RP01-400
          50040-RP01-200
          50040-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart

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          IGF-2/IGF-II protein 背景

          Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. IGF-2 and exhibited statistically significant, positive associations with colorectal cancer risk when cases were confined to those diagnosed within a relatively short time period after enrolment. Circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer. IGF-2/IGF-II appears to be involved in the progression of many tumours. It binds to at least two different types of receptor: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumour suppressor function—it mediates IGF 2 degradation. Mutation of M6-P/IGF 2R causes both diminished growth suppression and augmented growth stimulation. The aim of this study was to investigate the role of IGF 2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer.

          人々 IGF-2/IGF-II protein 参考文献
        • Harvey MB, et al. (1991) IGF-2 receptors are first expressed at the 2-cell stage of mouse development. Development. 111(4): 1057-60.
        • Peters G, et al. (2003) IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 443(2): 139-45.
        • Burrow S, et al. (1998) Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. J Surg Oncol. 69(1): 21-7.
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