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CD40 / TNFRSF5 抗体, ウサギポリクローナル抗体

データシートレビュープロトコル
発現宿主: Human Cells  
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10774-H02H-50
10774-H02H-100
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100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
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10774-H08H-50
10774-H08H-100
50 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
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10774-H03H-50
10774-H03H-100
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100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
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50324-M03H-50
50324-M03H-100
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発現宿主: Human Cells  
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80151-R02H-50
80151-R02H-100
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100 µg 
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発現宿主: Human Cells  
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80151-R08H-50
80151-R08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
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70105-D02H-50
70105-D02H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
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70105-D08H-50
70105-D08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
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70105-DCCH-50
70105-DCCH-100
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発現宿主: Human Cells  
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90097-C08H-50
90097-C08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
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90097-C02H-50
90097-C02H-100
50 µg 
100 µg 
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CD40/TNFRSF5 antibody 背景

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

ラット CD40/TNFRSF5 antibody 参考文献
  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.
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