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人々 IL2Ra / CD25 蛋白質 (His タグ)

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反応度: Human  
アプリケーション: ELISA  
    10165-R702-50
    10165-R702-100
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    100 µg 
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    反応度: Human  
    アプリケーション: FCM  
    • Slide 1
    10165-R216-A-25
    10165-R216-A-100
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    反応度: Human  
    アプリケーション: FCM  
    • Slide 1
    10165-R216-50
    10165-R216-100
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    100 µg 
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    反応度: Human  
    アプリケーション: ELISA  
      10165-RP02-50
      10165-RP02-200
      10165-RP02-100
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      200 µg 
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      反応度: Human  
      アプリケーション: 
      • Slide 1
      10165-MM17-F-25
      10165-MM17-F-100
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      反応度: Human  
      アプリケーション: FCM  
      • Slide 1
      • Slide 1
      10165-R216-P-25
      10165-R216-P-100
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      100 Tests 
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      反応度: Human  
      アプリケーション: 
      • Slide 1
      • Slide 1
      10165-R216-F-25
      10165-R216-F-100
      25 Test 
      100 Tests 
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      反応度: Human  
      アプリケーション: ELISA  
        10165-MM14-50
        10165-MM14-200
        10165-MM14-100
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        200 µg 
        100 µg 
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        反応度: Human  
        アプリケーション: 
        • Slide 1
        10165-MM17-50
        10165-MM17-200
        10165-MM17-100
        50 µg 
        200 µg 
        100 µg 
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        反応度: Human  
        アプリケーション: 
        • Slide 1
        10165-MM17-P-25
        10165-MM17-P-100
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        反応度: Human  
        アプリケーション: ELISA  
          10165-RP01-400
          10165-RP01-200
          10165-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          反応度: Human  
          アプリケーション: 
          • Slide 1
          10165-R216-C-25
          10165-R216-C-100
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          反応度: Mouse  
          アプリケーション: FCM  
          • Slide 1
          • Slide 1
          50292-R051-P-25
          50292-R051-P-100
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          反応度: Mouse  
          アプリケーション: ELISA  
            50292-RP01-400
            50292-RP01-200
            50292-RP01-100
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            200 µg 
            100 µg 
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            反応度: Mouse  
            アプリケーション: ELISA  
              50292-R186-50
              50292-R186-100
              50 µg 
              100 µg 
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              反応度: Mouse  
              アプリケーション: FCM  
              • Slide 1
              50292-R049-50
              50292-R049-100
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              100 µg 
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              反応度: Mouse  
              アプリケーション: ELISA  
                50292-RP02-50
                50292-RP02-200
                50292-RP02-100
                50 µg 
                200 µg 
                100 µg 
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                反応度: Mouse  
                アプリケーション: FCM  
                • Slide 1
                • Slide 1
                50292-R049-F-25
                50292-R049-F-100
                25 Test 
                100 Tests 
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                反応度: Mouse  
                アプリケーション: FCM  
                • Slide 1
                • Slide 1
                50292-R049-A-25
                50292-R049-A-100
                25 Test 
                100 Tests 
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                反応度: Mouse  
                アプリケーション: FCM  
                • Slide 1
                • Slide 1
                50292-R049-P-25
                50292-R049-P-100
                25 Test 
                100 Tests 
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                反応度: Mouse  
                アプリケーション: FCM  
                • Slide 1
                50292-R051-C-25
                50292-R051-C-100
                25 Test 
                100 Tests 
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                反応度: Mouse  
                アプリケーション: FCM  
                • Slide 1
                • Slide 1
                50292-R051-A-25
                50292-R051-A-100
                25 Test 
                100 Tests 
                Add to Cart
                反応度: Mouse  
                アプリケーション: FCM  
                • Slide 1
                50292-R049-C-25
                50292-R049-C-100
                25 Test 
                100 Tests 
                Add to Cart
                反応度: Mouse  
                アプリケーション: FCM  
                • Slide 1
                50292-R051-50
                50292-R051-100
                50 µg 
                100 µg 
                Add to Cart
                反応度: Mouse  
                アプリケーション: FCM  
                • Slide 1
                • Slide 1
                50292-R051-F-25
                50292-R051-F-100
                25 Test 
                100 Tests 
                Add to Cart

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                IL2RA/IL-2RA/CD25 protein 背景

                CD25 (alpha-chain of IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling. The IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes (T1D). Cancer growth and development is associated with the stimulation of the innate immune system, including enhanced interleukin 2 receptor (IL-2R) expression in immune cells and its shedding into the circulation in a soluble form of sIL-2Ralpha. In most haematological malignancies, including different types of leukaemias and lymphomas, sIL-2Ralpha has been found to be released directly from the surface of neoplastic cells thus reflecting the tumour bulk, turnover and activity. Several studies have proved that not only lymphoid cancer cells, but also some non-lymphoid cancer cells, express IL-2R on their surface. They include malignant melanoma and carcinomas of the kidney, head and neck, oesophagus and lung. Thus, sIL-2Ralpha is elevated in most proliferative disturbances of the hematopoietic system and in many solid tumors.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                人々 IL2RA/IL-2RA/CD25 protein 参考文献
              • Driesen J, et al. (2008) CD25 as an immune regulatory molecule expressed on myeloid dendritic cells. Immunobiology. 213(9-10): 849-58.
              • Olejniczak K, et al. (2008) Biological properties of interleukin 2 and its role in pathogenesis of selected diseases--a review. Med Sci Monit. 14(10): RA179-89.
              • Chistiakov DA, et al. (2008) The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett. 118(1): 1-5.
              • Bien E, et al. (2008) Serum soluble interleukin 2 receptor alpha in human cancer of adults and children: a review. Biomarkers. 13(1): 1-26.
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