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人々 IL11RA/IL-11RA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag タグ

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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10252-H08H-50
10252-H08H-100
50 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
50075-M08H-200
50075-M08H-100
200 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
70078-DCCH-50
70078-DCCH-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
70078-D02H-50
70078-D02H-200
50 µg 
200 µg 
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発現宿主: Human Cells  
  • Slide 1
70078-D08H-50
70078-D08H-100
50 µg 
100 µg 
Add to Cart
反応度: Human  
アプリケーション: ELISA  WB  IP  
  • Slide 1
  • Slide 1
10252-T52-50
10252-T52-200
10252-T52-100
50 µg 
200 µg 
100 µg 
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反応度: Mouse  
アプリケーション: ELISA  
    50075-T16-50
    50075-T16-200
    50075-T16-100
    50 µg 
    200 µg 
    100 µg 
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    反応度: Mouse  
    アプリケーション: ELISA  
      50075-RP01-400
      50075-RP01-200
      50075-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反応度: Mouse  
      アプリケーション: ELISA  
        50075-R025-50
        50075-R025-100
        50 µg 
        100 µg 
        Add to Cart

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        IL11RA/IL-11RA cdna-clone 背景

        Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.

        人々 IL11RA/IL-11RA cdna-clone 参考文献
      • Van Leuven F, et al. (1996) Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. Genomics. 31 (1): 65-70.
      • Yoshizaki A, et al. (2006) Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. Int J Oncol. 29 (4): 869-76.
      • Karube K, et al. (2006) Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha. Ann Oncol. 17 (1): 110-6.
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