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人々 Complement component 7 Gene ORF cDNA clone expression plasmid, N-HA タグ

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発現宿主: Human Cells  
  • Slide 1
13848-H08H-20
13848-H08H-100
20 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
13848-H02H-20
13848-H02H-100
20 µg 
100 µg 
Add to Cart
反応度: Human  
アプリケーション: ELISA  
    13848-R009-50
    13848-R009-100
    50 µg 
    100 µg 
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    反応度: Human  
    アプリケーション: ELISA  
      13848-RP01-400
      13848-RP01-200
      13848-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反応度: Human  
      アプリケーション: ELISA  
        13848-T16-50
        13848-T16-200
        13848-T16-100
        50 µg 
        200 µg 
        100 µg 
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        反応度: Human  
        アプリケーション: 
          13848-R113-50
          13848-R113-100
          13848-R113-1
          50 µg 
          100 µg 
          1 mg 
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          Complement component 7 cdna-clone 背景

          Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

          人々 Complement component 7 cdna-clone 参考文献
        • Bossi F, et al. (2009) C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. Blood. 113(15):3640-8.
        • Kuijpers TW, et al. (2010) Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease. Mol Immunol. 47(4):671-7.
        • Thomas AD, et al. (2012) Characterization of a large genomic deletion in four Irish families with C7 deficiency. Mol Immunol. 50(1-2):57-9.
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