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人々 UBASH3A Gene ORF cDNA clone expression plasmid, N-HA タグ

データシートレビュープロトコル
反応度: Human  
アプリケーション: ELISA  IHC-P  
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13847-T24-50
13847-T24-200
13847-T24-100
50 µg 
200 µg 
100 µg 
Add to Cart
反応度: Human  
アプリケーション: ELISA  
    13847-RP01-400
    13847-RP01-200
    13847-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反応度: Human  
    アプリケーション: ELISA  
      13847-R101-50
      13847-R101-100
      50 µg 
      100 µg 
      Add to Cart

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      UBASH3A cdna-clone 背景

      UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of UBASH3A gene results in multiple transcript variants. It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. UBASH3A promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. UBASH3A also exhibits negligigle protein tyrosine phosphatase activity at neutral pH. It may act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. It may also inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

      人々 UBASH3A cdna-clone 参考文献
    • Collingwood TS, et al. (2007) T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.". J. Biol. Chem. 282 (42): 30920-8.
    • Smirnova EV, et al. (2008) TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion. Virology. 372(1):10-23.
    • Wattenhofer M, et al. (2001) Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains. Hum Genet. 108(2):140-7.
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