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マウス Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, N-Flag タグ

データシートレビュープロトコル
反応度: Human  
アプリケーション: ELISA  
    10271-T16-50
    10271-T16-200
    10271-T16-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反応度: Human  
    アプリケーション: ELISA  
      10271-R340-50
      10271-R340-100
      50 µg 
      100 µg 
      Add to Cart
      反応度: Human  
      アプリケーション: ELISA  
        10271-RP01-400
        10271-RP01-200
        10271-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart

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        Osteoprotegerin/TNFRSF11B cdna-clone 背景

        Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

        マウス Osteoprotegerin/TNFRSF11B cdna-clone 参考文献
      • Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
      • Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
      • Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.
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