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人々 CD171 / N-CAML1 / L1CAM 蛋白質 (His タグ)

データシートレビュープロトコル
反応度: Human  
アプリケーション: ELISA  
    10140-RP01-400
    10140-RP01-200
    10140-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反応度: Human  
    アプリケーション: FCM  
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    • Slide 1
    10140-MM03-P-25
    10140-MM03-P-100
    25 Test 
    100 Tests 
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    反応度: Human  
    アプリケーション: FCM  
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    10140-MM03-A-25
    10140-MM03-A-100
    25 Test 
    100 Tests 
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    反応度: Human  
    アプリケーション: ELISA  
      10140-MM01-50
      10140-MM01-200
      10140-MM01-100
      50 µg 
      200 µg 
      100 µg 
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      反応度: Human  
      アプリケーション: FCM  
      • Slide 1
      10140-MM03-50
      10140-MM03-200
      10140-MM03-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反応度: Human  
      アプリケーション: ELISA  
        10140-R004-50
        10140-R004-100
        50 µg 
        100 µg 
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        反応度: Human  
        アプリケーション: IHC-P  FCM  IF  ICC/IF  
        • Slide 1
        • Slide 1
        • Slide 1
        10140-R014-50
        10140-R014-100
        10140-R014-1
        50 µg 
        100 µg 
        1 mg 
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        反応度: Human  
        アプリケーション: 
          10140-R001-50
          10140-R001-100
          10140-R001-1
          50 µg 
          100 µg 
          1 mg 
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          反応度: Human  
          アプリケーション: FCM  
          • Slide 1
          10140-R014-P-25
          10140-R014-P-100
          25 Test 
          100 Tests 
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          反応度: Human  
          アプリケーション: ELISA  
            10140-RP02-50
            10140-RP02-200
            10140-RP02-100
            50 µg 
            200 µg 
            100 µg 
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            反応度: Human  
            アプリケーション: FCM  
            • Slide 1
            10140-R014-F-25
            10140-R014-F-100
            25 Test 
            100 Tests 
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            反応度: Mouse  
            アプリケーション: 
            • Slide 1
            101901-T08-50
            101901-T08-200
            101901-T08-100
            50 µg 
            200 µg 
            100 µg 
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            CD171/L1CAM protein 背景

            L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.

            人々 CD171/L1CAM protein 参考文献
          • Meier F, et al. (2006) The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 119(3): 549-55.
          • Gavert N, et al. (2008) L1-CAM in cancerous tissues. Expert Opin Biol Ther. 8(11): 1749-57.
          • Issa Y, et al. (2009) Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J Mol Med. 87(1): 99-112.
          • Weidle UH, et al. (2009) L1-CAM as a target for treatment of cancer with monoclonal antibodies. Anticancer Res. 29(12): 4919-31.
          • Raveh S, et al. (2009) L1 cell adhesion molecule (L1CAM) in invasive tumors. Cancer Lett. 282(2): 137-45.
          • Wolterink S, et al. (2010) Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. Cancer Res. 70(6): 2504-15.
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