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マウス ACE2 / Angiotensin-Converting Enzyme 2 Gene ORF cDNA clone expression plasmid, C-His タグ

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製品の説明: Active  
発現宿主: Human Cells  
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10108-H02H-20
10108-H02H-10
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10 µg 
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発現宿主: Human Cells  
  • Slide 1
10108-H05H-50
10108-H05H-10
50 µg 
10 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
80031-R08H-20
80031-R08H-10
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10 µg 
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製品の説明: Active  
発現宿主: Human Cells  
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90211-C08H-20
90211-C08H-10
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10 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
90211-C02H-20
90211-C02H-10
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10 µg 
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反応度: Human  
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    10108-RP01-400
    10108-RP01-200
    10108-RP01-100
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    200 µg 
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    反応度: Human  
    アプリケーション: ELISA  WB  IHC-P  
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    • Slide 1
    • Slide 1
    10108-T56-50
    10108-T56-200
    10108-T56-100
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    200 µg 
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    反応度: Rat  
    アプリケーション: IHC-P  
    • Slide 1
    • Slide 1
    80031-R039-50
    80031-R039-100
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    反応度: Rat  
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      80031-R003-50
      80031-R003-100
      80031-R003-1
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      1 mg 
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      反応度: Rat  
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        80031-MM04-50
        80031-MM04-200
        80031-MM04-100
        80031-MM04-1
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        200 µg 
        100 µg 
        1 mg 
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        反応度: Rat  
        アプリケーション: ELISA  
          80031-RP02-50
          80031-RP02-200
          80031-RP02-100
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          200 µg 
          100 µg 
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          反応度: Rat  
          アプリケーション: ELISA  
            80031-RP01-400
            80031-RP01-200
            80031-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            反応度: Rat  
            アプリケーション: ELISA  
              80031-R001-50
              80031-R001-100
              50 µg 
              100 µg 
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              ACE2 / Angiotensin-Converting Enzyme 2 cdna-clone 背景

              Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.

              マウス ACE2 / Angiotensin-Converting Enzyme 2 cdna-clone 参考文献
            • Koitka A, et al. (2008) Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol. 35(4): 420-5.
            • Raizada MK, et al. (2007) ACE2: a new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50(2): 112-9.
            • Imai Y, et al. (2007) Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3): 405-10.
            • Turner AJ, et al. (2004) ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 25(6): 291-4.
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