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人々 IL-1 alpha / IL1A / IL1F1 HEK293 細胞溶解物; (WB 陽性対照)

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製品の説明: Active  
発現宿主: Human Cells  
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10128-HNCH-5
10128-HNCH-20
10128-HNCH-100
5 µg 
20 µg 
100 µg 
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製品の説明: Active  
発現宿主: E. coli  
  • Slide 1
50114-MNAE-5
50114-MNAE-20
50114-MNAE-100
5 µg 
20 µg 
100 µg 
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反応度: Human  
アプリケーション: ELISA  
    10128-T16-50
    10128-T16-200
    10128-T16-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反応度: Human  
    アプリケーション: ELISA  
      10128-RP01-400
      10128-RP01-200
      10128-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反応度: Human  
      アプリケーション: ELISA  
        10128-R004-50
        10128-R004-100
        50 µg 
        100 µg 
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        反応度: Mouse  
        アプリケーション: ELISA  
          50114-RP01-400
          50114-RP01-200
          50114-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          反応度: Mouse  
          アプリケーション: 
            50114-R148-50
            50114-R148-100
            50114-R148-1
            50 µg 
            100 µg 
            1 mg 
            Add to Cart
            反応度: Mouse  
            アプリケーション: ELISA  IHC-P  
            • Slide 1
            50114-RP02-50
            50114-RP02-200
            50114-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            反応度: Mouse  
            アプリケーション: 
            • Slide 1
            • Slide 1
            50114-T52-50
            50114-T52-200
            50114-T52-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            反応度: Mouse  
            アプリケーション: ELISA  
              50114-T16-50
              50114-T16-200
              50114-T16-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              反応度: Mouse  
              アプリケーション: ELISA  
                50114-R024-50
                50114-R024-100
                50 µg 
                100 µg 
                Add to Cart

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                IL1A/IL-1A/IL-1F1 lysate_category 背景

                IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                人々 IL1A/IL-1A/IL-1F1 lysate_category 参考文献
              • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
              • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
              • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
              • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.
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