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人々 JAML / AMICA 蛋白質 (His タグ)

データシートレビュープロトコル
反応度: Human  
アプリケーション: ELISA  
    10120-MM08-50
    10120-MM08-200
    10120-MM08-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反応度: Human  
    アプリケーション: FCM  
    • Slide 1
    10120-MM02-50
    10120-MM02-200
    10120-MM02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反応度: Human  
    アプリケーション: 
      10120-MM06-50
      10120-MM06-200
      10120-MM06-100
      10120-MM06-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
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      反応度: Human  
      アプリケーション: ELISA  
        10120-RP02-50
        10120-RP02-200
        10120-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反応度: Human  
        アプリケーション: FCM  
        • Slide 1
        • Slide 1
        10120-MM02-F-25
        10120-MM02-F-100
        25 Test 
        100 Tests 
        Add to Cart
        反応度: Human  
        アプリケーション: FCM  
        • Slide 1
        10120-MM02-A-25
        10120-MM02-A-100
        25 Test 
        100 Tests 
        Add to Cart
        反応度: Human  
        アプリケーション: 
          10120-MM05-50
          10120-MM05-200
          10120-MM05-100
          10120-MM05-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
          Add to Cart
          反応度: Human  
          アプリケーション: ELISA  
            10120-RP01-400
            10120-RP01-200
            10120-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            反応度: Human  
            アプリケーション: FCM  
            • Slide 1
            • Slide 1
            10120-MM02-P-25
            10120-MM02-P-100
            25 Test 
            100 Tests 
            Add to Cart

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            JAML/AMICA1 protein 背景

            Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells.

            人々 JAML/AMICA1 protein 参考文献
          • Moog-Lutz C, et al. (2003) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood. 102(9): 3371-8.
          • Luissint AC, et al. (2008) JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. J Cell Biol. 183(6): 1159-73.
          • Guo YL, et al. (2009) Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. Arterioscler Thromb Vasc Biol. 29(1): 75-83.
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