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マウス SOD1 Gene ORF cDNA clone expression plasmid, N-Flag タグ

データシートレビュープロトコル
反応度: Human  
アプリケーション: 
    11727-MM10-50
    11727-MM10-200
    11727-MM10-100
    11727-MM10-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
    反応度: Human  
    アプリケーション: FCM  
    • Slide 1
    11727-R106-P-25
    11727-R106-P-100
    25 Test 
    100 Tests 
    Add to Cart
    反応度: Human  
    アプリケーション: FCM  
    • Slide 1
    11727-MM11-F-25
    11727-MM11-F-100
    25 Test 
    100 Tests 
    Add to Cart
    反応度: Human  
    アプリケーション: FCM  
    • Slide 1
    11727-R106-50
    11727-R106-100
    50 µg 
    100 µg 
    Add to Cart
    反応度: Human  
    アプリケーション: ELISA  
      11727-RP01-400
      11727-RP01-200
      11727-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反応度: Human  
      アプリケーション: FCM  
      • Slide 1
      11727-MM11-P-25
      11727-MM11-P-100
      25 Test 
      100 Tests 
      Add to Cart
      反応度: Human  
      アプリケーション: WB  FCM  IP  
      • Slide 1
      • Slide 1
      • Slide 1
      • Slide 1
      • Slide 1
      • Slide 1
      11727-MM11-50
      11727-MM11-200
      11727-MM11-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反応度: Human  
      アプリケーション: ELISA  IF  ICC/IF  
      • Slide 1
      11727-R101-50
      11727-R101-100
      50 µg 
      100 µg 
      Add to Cart
      反応度: Human  
      アプリケーション: FCM  
      • Slide 1
      11727-R106-F-25
      11727-R106-F-100
      25 Test 
      100 Tests 
      Add to Cart
      反応度: Human  
      アプリケーション: ELISA  WB  IP  
      • Slide 1
      • Slide 1
      11727-RP02-50
      11727-RP02-200
      11727-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart

      SOD1 ELISA Pair Set

      検出限界:
      SEK11727-5
      SEK11727-15
      5 Plates 
      15 Plates 
      Add to Cart

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      SOD1 cdna-clone 背景

      SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. SOD1 destroys radicals which are normally produced within the cells and which are toxic to biological systems. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1). ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.

      マウス SOD1 cdna-clone 参考文献
    • Murakami K, et al. (2011) SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. J Biol Chem. 286(52):44557-68.
    • Thompson M, et al. (2012) Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis. J Neurochem. 120(4):598-610.
    • Magrané J, et al. (2012) Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons. J Neurosci. 32(1):229-42.
    • Gertz B, et al. (2012) Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice. J Neuropathol Exp Neurol. 71(2):162-77.
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