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人々 Calsequestrin-1 / CASQ1 Gene ORF cDNA clone expression plasmid, N-HA タグ

データシートレビュープロトコル
反応度: Human  
アプリケーション: ELISA  IHC-P  
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13805-T16-50
13805-T16-200
13805-T16-100
50 µg 
200 µg 
100 µg 
Add to Cart
反応度: Human  
アプリケーション: 
  • Slide 1
  • Slide 1
  • Slide 1
13805-T60-50
13805-T60-200
13805-T60-100
50 µg 
200 µg 
100 µg 
Add to Cart

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Calsequestrin-1 / CASQ1 cdna-clone 背景

Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-bound calcium (through a calcium release channel) triggers muscle contraction. The active protein is not highly structured, more than 50% of it adopting a random coil conformation. When calcium binds there is a structural change whereby the alpha-helical content of the protein increases from 3 to 11%. Both forms of calsequestrin are phosphorylated by casein kinase 2, but the cardiac form is phosphorylated more rapidly and to a higher degree. Calsequestrin-1 is also secreted in the gut where it deprives bacteria of calcium ions.

人々 Calsequestrin-1 / CASQ1 cdna-clone 参考文献
  • Slupsky JR, et al. (1987) Characterization of cardiac calsequestrin. Biochemistry. 26(20): 6539-44.
  • Cala SE, et al. (1991) Phosphorylation of cardiac and skeletal muscle calsequestrin isoforms by casein kinase II. Demonstration of a cluster of unique rapidly phosphorylated sites in cardiac calsequestrin. J Biol Chem. 266(1):391-8.
  • Wang S, et al. (1998) Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum. Nat Struct Biol. 5(6):476-83.
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