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人々 IL1R2 / IL1RB / CD121b HEK293 細胞溶解物; (WB 陽性対照)

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製品の説明: Active  
発現宿主: Human Cells  
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10111-H02H-50
10111-H02H-100
50 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10111-H08H-50
10111-H08H-100
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100 µg 
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発現宿主: Human Cells  
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10111-HCCH-50
10111-HCCH-100
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100 µg 
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発現宿主: Human Cells  
  • Slide 1
51090-M08H-200
51090-M08H-100
200 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
51090-M02H-50
51090-M02H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
80196-R08H-50
80196-R08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
90120-C02H-50
90120-C02H-100
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100 µg 
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発現宿主: Human Cells  
  • Slide 1
70093-D02H-50
70093-D02H-20
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20 µg 
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反応度: Human  
アプリケーション: ELISA  
    10111-RP02-50
    10111-RP02-200
    10111-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    反応度: Human  
    アプリケーション: ELISA  
      10111-MM11-50
      10111-MM11-200
      10111-MM11-100
      50 µg 
      200 µg 
      100 µg 
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      反応度: Human  
      アプリケーション: ELISA  
        10111-RP01-400
        10111-RP01-200
        10111-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        反応度: Human  
        アプリケーション: ELISA  
          10111-R020-50
          10111-R020-100
          50 µg 
          100 µg 
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          反応度: Human  
          アプリケーション: ELISA  
            10111-MM04-50
            10111-MM04-200
            10111-MM04-100
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            200 µg 
            100 µg 
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            反応度: Human  
            アプリケーション: 
              10111-MM02-50
              10111-MM02-200
              10111-MM02-100
              10111-MM02-1
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              200 µg 
              100 µg 
              1 mg 
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              反応度: Human  
              アプリケーション: 
                10111-R041-50
                10111-R041-100
                10111-R041-1
                50 µg 
                100 µg 
                1 mg 
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                反応度: Mouse  
                アプリケーション: ELISA  
                  51090-RP01-400
                  51090-RP01-200
                  51090-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
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                  反応度: Mouse  
                  アプリケーション: ELISA  
                    51090-T16-50
                    51090-T16-200
                    51090-T16-100
                    50 µg 
                    200 µg 
                    100 µg 
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                    反応度: Rat  
                    アプリケーション: 
                      80196-R161-50
                      80196-R161-100
                      80196-R161-1
                      50 µg 
                      100 µg 
                      1 mg 
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                      反応度: Rat  
                      アプリケーション: ELISA  
                        80196-MM05-50
                        80196-MM05-200
                        80196-MM05-100
                        80196-MM05-1
                        50 µg 
                        200 µg 
                        100 µg 
                        1 mg 
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                        反応度: Rat  
                        アプリケーション: ELISA  
                          80196-RP01-400
                          80196-RP01-200
                          80196-RP01-100
                          400 µg 
                          200 µg 
                          100 µg 
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                          反応度: Rat  
                          アプリケーション: ELISA  
                            80196-R021-50
                            80196-R021-100
                            50 µg 
                            100 µg 
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                            IL-1R2/CD121b ELISA Pair Set

                            検出限界:
                            SEK80196-5
                            SEK80196-15
                            5 Plates 
                            15 Plates 
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                            検出限界: 9.375 pg/ml
                            SEK10111-5
                            SEK10111-15
                            5 Plates 
                            15 Plates 
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                            IL-1R2/CD121b lysate_category 背景

                            Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

                            人々 IL-1R2/CD121b lysate_category 参考文献
                          • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
                          • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
                          • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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