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マウス IL12A / IL-12A transcript variant 1 Gene ORF cDNA clone in cloning vector

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発現宿主: Human Cells  
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10021-H02H-50
10021-H02H-20
50 µg 
20 µg 
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製品の説明: Active  
発現宿主: Human Cells  
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10021-H08H-500
10021-H08H-5
10021-H08H-20
10021-H08H-100
10021-H08H-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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発現宿主: Human Cells  
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90290-C02H-50
90290-C02H-20
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20 µg 
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反応度: Human  
アプリケーション: ELISA  
    10021-MM05-50
    10021-MM05-200
    10021-MM05-100
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    200 µg 
    100 µg 
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    反応度: Human  
    アプリケーション: ELISA  
      10021-RP01-400
      10021-RP01-200
      10021-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反応度: Human  
      アプリケーション: ELISA  
        10021-R006-50
        10021-R006-100
        50 µg 
        100 µg 
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        反応度: Human  
        アプリケーション: ELISA  WB  IHC-P  
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        10021-RP02-50
        10021-RP02-200
        10021-RP02-100
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        200 µg 
        100 µg 
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        反応度: Mouse  
        アプリケーション: WB  
        • Slide 1
        100321-T32-50
        100321-T32-200
        100321-T32-100
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        200 µg 
        100 µg 
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        IL12A / IL-12A cdna-clone 背景

        Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 alpha chain. IL12A/IL-12p35 is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A/IL-12p35 is required for the T-cell-independent induction of IFN-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. In clinical, IL-12 remains a very promising immunotherapeutic agent because recent cancer vaccination studies in animal models and humans have demonstrated its powerful adjuvant properties. The immune modulating characteristics of IL-12 considered responsible for the adjuvant effects, as well as the results of animal and human cancer vaccination studies with IL-12 applied as an adjuvant. IL12A/IL-12p35 indicates a cytokine which is important in the development of prostate cancer.

        マウス IL12A / IL-12A cdna-clone 参考文献
      • Sattler HP, et al. (2000) Novel amplification unit at chromosome 3q25-q27 in human prostate cancer. Prostate. 45(3): 207-15.
      • Lamont AG, et al. (1996) IL-12: a key cytokine in immune regulation. Immunol Today. 17(5): 214-7.
      • Portielje JE, et al. (2003) IL-12: a promising adjuvant for cancer vaccination. Cancer Immunol Immunother. 52(3): 133-44.
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