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マウス IL-1F5 Gene ORF cDNA clone expression plasmid, C-His タグ

データシートレビュープロトコル
発現宿主: E. coli  
  • Slide 1
10125-HNAE-50
10125-HNAE-20
50 µg 
20 µg 
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発現宿主: E. coli  
  • Slide 1
50213-MNAE-50
50213-MNAE-20
50 µg 
20 µg 
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反応度: Human  
アプリケーション: ELISA  
    10125-RP01-400
    10125-RP01-200
    10125-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反応度: Human  
    アプリケーション: ELISA  
      10125-R002-50
      10125-R002-100
      50 µg 
      100 µg 
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      反応度: Human  
      アプリケーション: ELISA  
        10125-T16-50
        10125-T16-200
        10125-T16-100
        50 µg 
        200 µg 
        100 µg 
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        反応度: Human  
        アプリケーション: ELISA  
          10125-MM04-50
          10125-MM04-200
          10125-MM04-100
          50 µg 
          200 µg 
          100 µg 
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          反応度: Mouse  
          アプリケーション: ELISA  
            50213-R022-50
            50213-R022-100
            50 µg 
            100 µg 
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            反応度: Mouse  
            アプリケーション: ELISA  
              50213-RP01-400
              50213-RP01-200
              50213-RP01-100
              400 µg 
              200 µg 
              100 µg 
              Add to Cart
              反応度: Mouse  
              アプリケーション: 
              • Slide 1
              50213-T24-50
              50213-T24-200
              50213-T24-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              反応度: Mouse  
              アプリケーション: ELISA  
                50213-T16-50
                50213-T16-200
                50213-T16-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart

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                IL-1F5 cdna-clone 背景

                Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR−/− mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.

                マウス IL-1F5 cdna-clone 参考文献
              • Nicklin MJ, et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19 (2): 382-4.
              • Debets R, et al. (2001) Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J Immunol. 167 (3): 1440-6.
              • Costelloe C, et al. (2008) IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem. 105(5): 1960-9.
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