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Carbonic Anhydrase IX / CA9 抗体, ウサギモノクローナル抗体

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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10107-H02H-20
10107-H02H-10
20 µg 
10 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10107-H08H-20
10107-H08H-100
10107-H08H-10
20 µg 
100 µg 
10 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
50660-M08H-20
50660-M08H-10
20 µg 
10 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
70028-D08H-20
70028-D08H-10
20 µg 
10 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
70028-D02H-20
70028-D02H-10
20 µg 
10 µg 
Add to Cart

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Carbonic Anhydrase IX/CA9 antibody 背景

Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

人々 Carbonic Anhydrase IX/CA9 antibody 参考文献
  • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
  • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
  • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
  • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.
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