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人々 Carbonic Anhydrase IX / CA9 HEK293 細胞溶解物; (WB 陽性対照)

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製品の説明: Active  
発現宿主: Human Cells  
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10107-H02H-20
10107-H02H-10
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製品の説明: Active  
発現宿主: Human Cells  
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10107-H08H-20
10107-H08H-100
10107-H08H-10
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製品の説明: Active  
発現宿主: Human Cells  
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50660-M08H-20
50660-M08H-10
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製品の説明: Active  
発現宿主: Human Cells  
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70028-D08H-20
70028-D08H-10
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製品の説明: Active  
発現宿主: Human Cells  
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70028-D02H-20
70028-D02H-10
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10 µg 
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反応度: Human  
アプリケーション: ELISA  WB  IP  
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  • Slide 1
  • Slide 1
10107-R003-50
10107-R003-100
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反応度: Human  
アプリケーション: ELISA  IHC-P  
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10107-RP02-50
10107-RP02-200
10107-RP02-100
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反応度: Human  
アプリケーション: 
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10107-T48-50
10107-T48-200
10107-T48-100
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反応度: Human  
アプリケーション: ELISA  
    10107-RP01-400
    10107-RP01-200
    10107-RP01-100
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    100 µg 
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    反応度: Human  
    アプリケーション: ELISA  IHC-P  
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    • Slide 1
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    10107-R005-50
    10107-R005-100
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    反応度: Human  
    アプリケーション: ELISA  FCM  
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    10107-R036-50
    10107-R036-100
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    反応度: Mouse  
    アプリケーション: ELISA  
      50660-RP01-400
      50660-RP01-200
      50660-RP01-100
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      200 µg 
      100 µg 
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      反応度: Mouse  
      アプリケーション: ELISA  WB  IHC-P  
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      • Slide 1
      • Slide 1
      50660-RP02-50
      50660-RP02-200
      50660-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      反応度: Mouse  
      アプリケーション: IHC-P  
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      50660-R001-50
      50660-R001-100
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      100 µg 
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      反応度: Canine  
      アプリケーション: ELISA  WB  IP  
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      70028-T52-50
      70028-T52-200
      70028-T52-100
      50 µg 
      200 µg 
      100 µg 
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      反応度: Canine  
      アプリケーション: ELISA  
        70028-RP01-400
        70028-RP01-200
        70028-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart

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        Carbonic Anhydrase IX/CA9 lysate_category 背景

        Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

        Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

        人々 Carbonic Anhydrase IX/CA9 lysate_category 参考文献
      • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
      • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
      • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
      • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.
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