Mcl-1 cDNA ORF Clone in Cloning Vector, Human

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Mcl-1 cDNA ORF Clone in Cloning Vector, Human: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
1053 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence.
製品の特徴
Full length Clone DNA of Human myeloid cell leukemia sequence 1 (BCL2-related), transcript variant 1.
プラスミド
ベクター
シークエンシングプライマー
M13-47 and RV-M
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

Mcl-1 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Mcl-1 cDNA ORF Clone in Cloning Vector, Human: 別名

bcl2-L-3 cDNA ORF Clone, Human; BCL2L3 cDNA ORF Clone, Human; EAT cDNA ORF Clone, Human; Mcl-1 cDNA ORF Clone, Human; MCL1-ES cDNA ORF Clone, Human; mcl1/EAT cDNA ORF Clone, Human; MCL1L cDNA ORF Clone, Human; MCL1S cDNA ORF Clone, Human; TM cDNA ORF Clone, Human

Mcl-1 背景情報

MCL1 is an anti-apoptotic protein in BCL2 family, and amplifies frequently in multiple human cancers.Myeloid cell leukemia sequence 1 (MCL1) is a potent antiapoptotic protein that plays a critical role in cell survival and drug resistance in various cancers.MCL1 is a pivot member of the anti-apoptotic BCL-2 family proteins. While a distinctive feature of MCL1 resides in its efficient ubiquitination and destruction, the deubiquitinase USP9X has been implicated in the preservation of MCL1 expression by removing the polyubiquitin chains.MCL1 is also known as a potential contributor for the resistance of BCL2 inhibitors, as well as various chemotherapeutic drugs. MCL1 is, therefore, regarded as a potential target for cancer therapy.The overexpression of MCL1 promotes cell survival and confers chemotherapeutic resistance.
完全な名称
myeloid cell leukemia 1
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